Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

被引：65

作者：

Barnig, Cindy ^{[1
,2
]}

Bezema, Tjitske ^{[3
]}

Calder, Philip C. ^{[4
,5
,6
]}

Charloux, Anne ^{[1
,2
]}

Frossard, Nelly ^{[7
,8
]}

Garssen, Johan ^{[9
,10
]}

Haworth, Oliver ^{[11
,12
]}

Dilevskaya, Ksenia ^{[13
]}

Levi-Schaffer, Francesca ^{[14
]}

Lonsdorfer, Evelyne ^{[1
,2
]}

Wauben, Marca ^{[15
]}

Kraneveld, Aletta D. ^{[9
,16
]}

te Velde, Anje A. ^{[17
]}

机构：

[1] Strasbourg Univ Hosp, Dept Chest Dis, Strasbourg, France

[2] Univ Strasbourg, Equipe Accueil 3072, Strasbourg, France

[3] Immunowell Fdn, Utrecht, Netherlands

[4] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England

[5] Univ Hosp Southampton NHS Fdn Trust, Southampton Biomed Res Ctr, Natl Inst Hlth Res, Southampton, Hants, England

[6] Univ Southampton, Southampton, Hants, England

[7] Univ Strasbourg, CNRS, UMR 7200, Lab Innovat Therapeut, Strasbourg, France

[8] Fac Pharm, LabEx MEDALIS, Strasbourg, France

[9] Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacol, Utrecht, Netherlands

[10] Nutricia Res, Utrecht, Netherlands

[11] Barts Sch Med, William Harvey Res Inst, Biochem Pharmacol, London, England

[12] Queen Mary Univ London, London, England

[13] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, Div Pharmacol, Utrecht, Netherlands

[14] Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, Fac Med,Pharmacol & Expt Therapeut Unit, Jerusalem, Israel

[15] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Utrecht, Netherlands

[16] Univ Utrecht, Fac Vet Med, Inst Risk Assessment Sci, Utrecht, Netherlands

[17] Univ Amsterdam, AGEM, Tytgat Inst Liver & Intestinal Res, Amsterdam UMC, Amsterdam, Netherlands

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

以色列科学基金会;

关键词：

resolution; inflammation; immune fitness; eicosanoids; asthma; chronic inflammatory bowel disease; REGULATORY T-CELLS; PRO-RESOLVING MEDIATORS; VASOACTIVE-INTESTINAL-PEPTIDE; INNATE LYMPHOID-CELLS; MELANOCYTE-STIMULATING HORMONE; ALLERGIC AIRWAY INFLAMMATION; GROWTH-FACTOR-BETA; POLYUNSATURATED FATTY-ACIDS; ACTIVE ULCERATIVE-COLITIS; HYDROGEN-SULFIDE;

D O I：

10.3389/fimmu.2019.01699

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in "Th1/Th17 cell-driven" immune diseases and "Th2 cell-driven" immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases.

引用

页数：19

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