Protective effect of zerumbone reduces lipopolysaccharide-induced acute lung injury via antioxidative enzymes and Nrf2/HO-1 pathway

被引：55

作者：

Leung, Wai-Shing ^{[1
]}

Yang, Ming-Ling ^{[2
]}

Lee, Shiuan-Shinn ^{[3
]}

Kuo, Chi-Wen ^{[4
,5
]}

Ho, Yung-Chyuan ^{[6
]}

Huang-Liu, Rosa ^{[7
]}

Lin, Hui-Wen ^{[8
,9
]}

Kuan, Yu-Hsiang ^{[10
,11
]}

机构：

[1] Jen Ai Hosp, Dept Emergency Med, Taichung, Taiwan

[2] Chung Shan Med Univ, Sch Med, Dept Anat, Taichung, Taiwan

[3] Chung Shan Med Univ, Sch Publ Hlth, Taichung, Taiwan

[4] Jen Ai Hosp, Dept Pharmacol, Taichung, Taiwan

[5] Cent Taiwan Univ Sci & Technol, Taichung, Taiwan

[6] Chung Shan Med Univ, Sch Med Appl Chem, Taichung, Taiwan

[7] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan

[8] Asia Univ, Dept Optometry, Taichung, Taiwan

[9] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[10] Chung Shan Med Univ, Sch Med, Dept Pharmacol, Taichung 40201, Taiwan

[11] Cluing Shan Med Univ Hosp, Dept Pharm, Taichung 40201, Taiwan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2017年 / 46卷

关键词：

Zerumbone; LPS; Acute lung injury; Antioxidative enzymes; Nrf2; HO-1; NF-KAPPA-B; BILOBA LEAVES EXTRACT; AKT PHOSPHORYLATION; OXIDATIVE STRESS; CARBON-MONOXIDE; INHIBITION; MICE; INFLAMMATION; EXPRESSION; RUTIN;

D O I：

10.1016/j.intimp.2017.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute lung injury (ALI) is a serious disease with high morbidity and mortality rate. Although there are effective strategies for treatment of ALI; a widely accepted specific pharmacotherapy has not yet established. Zerumbone, the major active phytochemical compound from Zingiber zerumbet Smith, exhibits various beneficial biological and pharmacological activities, such as antioxidation, anti-inflammation, immunomodulation, and anti-cancer. We aimed to study the potential protective effects and mechanisms of zerumbone in mouse model of lipopolysaccharide (LPS)-induced ALI Pretreatment with zerumbone inhibited the histopatholgical changes such as neutrophils infiltration, increased in alveolar barrier thickness, hemorrhage, and hyaline membrane formation occurred in lungs in LPS-induced ALI. In addition, not only LPS-induced activation of myeloperoxidase (MPO) and metallopeptidase-9 (MMP-9) was suppressed by zerumbone, but also lipid peroxidation in lungs was inhibited as well. Moreover, pretreatment with zerumbone reversed the antioxidative enzymes activities, including superoxide dismutase, catalase, and glutathione peroxidase, decreased by LPS and enhanced the expression of nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase (HO-1) induced by LPS. These results from present study suggested that the protective mechanisms of zerumbone on LPS-induced ALI were via up regulation of antioxidative enzymes and Nrf2/HO-1 pathway. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：194 / 200

页数：7

共 41 条

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