Virological Response to Initial Antiretroviral Regimens Containing Abacavir or Tenofovir

被引：7

作者：

Bansi, Loveleen ^{[1
]}

Sabin, Caroline ^{[1
]}

Gilson, Richard ^{[1
]}

Gazzard, Brian ^{[2
]}

Leen, Clifford ^{[10
]}

Anderson, Jane ^{[3
]}

Dunn, David ^{[4
]}

Hill, Teresa ^{[1
]}

Fisher, Martin ^{[11
]}

Ainsworth, Jonathan ^{[5
]}

Pillay, Deenan ^{[6
]}

Johnson, Margaret

Walsh, John ^{[7
]}

Orkin, Chloe ^{[8
]}

Easterbrook, Philippa ^{[9
]}

Gompels, Mark ^{[12
]}

Phillips, Andrew ^{[1
]}

机构：

[1] UCL, Sch Med, London W1N 8AA, England

[2] Chelsea & Westminster Natl Hlth Serv NHS Trust, London W1N 8AA, England

[3] Homerton Univ Hosp NHS Trust, London, England

[4] MRC, Clin Trials Unit, London, England

[5] N Middlesex Univ Hosp NHS Trust, Middlesex, England

[6] UCL, Dept Virol, London NW3 2PF, England

[7] Imperial Coll Healthcare NHS Trust, London, England

[8] Barts & London NHS Trust, London, England

[9] Kings Coll Hosp, London, England

[10] Lothian Univ Hosp NHS Trust, Edinburgh, Midlothian, Scotland

[11] Brighton & Sussex Univ Hosp NHS Trust, Brighton, E Sussex, England

[12] N Bristol NHS Trust, Bristol, Avon, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 05期

基金：

英国医学研究理事会;

关键词：

HIV; COHORT;

D O I：

10.1086/605024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with a baseline viral load 1100,000 copies/mL receiving abacavir (ABC) as part of the nucleoside-backbone component of their first highly active antiretroviral therapy ( HAART) regimen have been reported to have a greater failure rate than those receiving tenofovir (TDF). We analyzed short-term outcomes of the use of HAART combinations that included ABC or TDF. The mean 2-8-week change in viral load was calculated using linear regression. In total, 1136 patients started ABC, and 412 started TDF. After adjustment for baseline viral load and other factors, there was no difference in the change in viral load between the patients who started ABC and those who started TDF (0.03 [95% confidence interval, -0.07 to 0.12]) log copies/mL; P = .59). Furthermore, there was no evidence that this effect differed according to baseline viral load (P = .88 for the interaction between pre-HAART viral load and nucleoside started). Likewise, there was no difference in rates of virological failure between the 2 drugs at 24-48 weeks after starting HAART.

引用

页码：710 / 714

页数：5

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