Impact of Maternal Age on Oocyte and Embryo Competence

被引：317

作者：

Cimadomo, Danilo ^{[1
]}

Fabozzi, Gemma ^{[1
]}

Vaiarelli, Alberto ^{[1
]}

Ubaldi, Nicolo ^{[2
]}

Ubaldi, Filippo Maria ^{[1
]}

Rienzi, Laura ^{[1
]}

机构：

[1] Genera, Ctr Reprod Med, Clin Valle Giulia, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Rome, Italy

来源：

FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷

关键词：

ovarian reserve; oocyte competence; aging; aneuploidies; IVF; IN-VITRO FERTILIZATION; MITOCHONDRIAL-DNA CONTENT; HUMAN FEMALE MEIOSIS; CHROMOSOME SEGREGATION; HUMAN BLASTOCYSTS; HUMAN ANEUPLOIDY; TELOMERE LENGTH; MEIOTIC ERRORS; COPY NUMBER; LIVE BIRTH;

D O I：

10.3389/fendo.2018.00327

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults, especially concerning an increased incidence of aneuploidies and possibly decreased mitochondria' activity. Age-related chromosomal abnormalities mainly arise because of meiotic impairments during oogenesis, following flawed chromosome segregation patterns such as non-disjunction, premature separation of sister chromatids, or the recent reverse segregation. In this review, we briefly discuss the main mechanisms putatively impaired by aging in the oocytes and the deriving embryos. We also report the main strategies proposed to improve the management of advanced maternal age women in IVF: fertility preservation through oocyte cryopreservation to prevent aging; optimization of the ovarian stimulation and enhancement of embryo selection to limit its effects; and oocyte donation to circumvent its consequences.

引用

页数：8

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