Formation of naproxen-polylactic acid nanoparticles from supercritical solutions and their characterization in the aerosol phase

被引：23

作者：

Gadermann, Moritz ^{[1
]}

Kular, Simran ^{[1
]}

Al-Marzouqi, Ali H. ^{[2
]}

Signorell, Ruth ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] United Arab Emirates Univ, Dept Chem & Petr Engn, Al Ain, U Arab Emirates

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2009年 / 11卷 / 36期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

PULSED RAPID EXPANSION; DRUG PARTICLES; FLUIDS;

D O I：

10.1039/b901744e

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Pure naproxen particles and mixed naproxen-polylactic acid particles were formed by pulsed rapid expansion of supercritical CO2 solutions (RESS). The characterization of the particles was carried out in the aerosol phase as a function of time after particle formation with rapid-scan infrared spectroscopy and with an aerosol particle sizer. After collection of the particles from the aerosol phase, the particles were characterized with scanning electron microscopy and powder diffraction. The present study shows clear evidence that RESS is capable of forming sub-micron naproxen particles that are coated with polylactic acid. Furthermore, it is demonstrated that coating with polylactic acid stabilizes the naproxen particles against agglomeration and coagulation.

引用

页码：7861 / 7868

页数：8

共 26 条

[1] Phase solubility and inclusion complex of itraconazole with β-cyclodextrin using supercritical carbon dioxide [J].

Al-Marzouqi, AH ;

Shehatta, I ;

Jobe, B ;

Dowaidar, A .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 95 (02) :292-304

[2]

Bohren C. F., 1998, ABSORPTION SCATTERIN, DOI 10.1002/9783527618156

[3] Characterization of the rapid expansion of supercritical solutions by Fourier transform infrared spectroscopy in situ -: art. no. 053904 [J].

Bonnamy, A ;

Hermsdorf, D ;

Ueberschaer, R ;

Signorell, R .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2005, 76 (05)

[4] APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES [J].

DEBENEDETTI, PG ;

TOM, JW ;

YEO, SD ;

LIM, GB .

JOURNAL OF CONTROLLED RELEASE, 1993, 24 (1-3) :27-44

[5] Large molecular aggregates: from atmospheric aerosols to drug nanoparticles [J].

Firanescu, George ;

Hermsdorf, Dana ;

Ueberschaer, Roman ;

Signorell, Ruth .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2006, 8 (36) :4149-4165

[6] Characterization of palmitic and lauric acid aerosols from rapid expansion of supercritical CO2 solutions [J].

Gadermann, Moritz ;

Preston, Thomas C. ;

Troster, Charles ;

Signorell, Ruth .

MOLECULAR PHYSICS, 2008, 106 (07) :945-953

[7] Infrared spectra of phenanthrene particles generated by pulsed rapid expansion of CO2 solutions [J].

Hermsdorf, D ;

Bonnamy, A ;

Suhm, MA ;

Signorell, R .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2004, 6 (19) :4652-4657

[8]

HERMSDORF D, 2006, THESIS U GOETTINGEN

[9] Formation and stabilization of ibuprofen nanoparticles by pulsed rapid expansion of supercritical solutions [J].

Hermsdorf, Dana ;

Jauer, Stephan ;

Signorell, Ruth .

MOLECULAR PHYSICS, 2007, 105 (08) :951-959

[10]

Hinds W. C, 1999, AEROSOL TECHNOLOGY

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