Bioactive clerodane diterpenes of giant goldenrod (Solidago gigantea Ait.) root extract

被引：18
作者：
Moricz, Agnes M. [1 ]
Kruezselyi, Daniel [1 ]
Ott, Peter G. [1 ]
Garadi, Zsofia [2 ]
Beni, Szabolcs [2 ]
Morlock, Gertrud E. [3 ,4 ]
Bakonyi, Jozsef [1 ]
机构：
[1] Ctr Agr Res, Plant Protect Inst, Herman O Str 15, H-1022 Budapest, Hungary
[2] Semmelweis Univ, Fac Pharm, Dept Pharmacognosy, Ulloi Str 26, H-1085 Budapest, Hungary
[3] Justus Liebig Univ Giessen, Inst Nutr Sci, Chair Food Sci, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany
[4] Justus Liebig Univ Giessen, TransMIT Ctr Effect Directed Anal, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany
来源：
JOURNAL OF CHROMATOGRAPHY A | 2021年 / 1635卷
关键词：
High-performance thin-layer chromatography - effect directed analysis; High-performance thin-layer chromatography - high-resolution mass; spectrometry; Fusarium avenaceum; Giant goldenrod (Solidago gigantea Ait.); Clerodane diterpenes; Antibacterials and antifungals; THIN-LAYER-CHROMATOGRAPHY; DIRECT BIOAUTOGRAPHY; FUSARIUM-AVENACEUM; IDENTIFICATION; ANTIBACTERIAL; CONSTITUENTS; RESISTANCE; HYPHENATIONS; METABOLISM; CANADENSIS;
D O I：
10.1016/j.chroma.2020.461727
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Giant goldenrod (Solidago gigantea Ait.) root extract was screened for bioactive compounds by high-performance thin-layer chromatography (HPTLC), coupled with effect-directed analysis including antibacterial (Bacillus subtilis F1276, B. subtilis subsp. spizizenii, Aliivibrio fischeri and Xanthomonas euvesicatoria), antifungal (Fusarium avenaceum) and enzyme inhibition (acetyland butyrylcholinesterases, alpha- and beta-glucosidases and alpha-amylase) assays. Compounds of six multipotent zones (Sg1-Sg6) were characterized by HPTLC-heated electrospray ionization-high-resolution mass spectrometry (HRMS) and HPTLC-Direct Analysis in Real Time-HRMS. Apart from zone Sg3, containing three compounds, a single characteristic compound was detectable in each bioactive zone. The bioassay-guided isolation using preparative-scale flash chromatography and high-performance liquid chromatography provided eight compounds that were identified by NMR spectroscopy as clerodane diterpenes. All isolates possessed inhibiting activity against at least one of the tested microorganisms. (C) 2020 The Author(s). Published by Elsevier B.V.
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页数：10
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