Peroxynitrite promotes immune evasion by reducing tumor antigenicity

被引：1
|
作者：
Capietto, Aude-Helene [1 ]
Delamarre, Lelia [1 ]
机构：
[1] Genentech Inc, Canc Immunol, 1 DNA Way, San Francisco, CA 94080 USA
来源：
CELL REPORTS MEDICINE | 2022年 / 3卷 / 10期
关键词：
ESCAPE;
D O I：
10.1016/j.xcrm.2022.100787
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically.
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页数：2
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