Exendin-4 analogs in insulinoma theranostics

被引：55
作者：
Jansen, Tom J. P. [1 ]
van Lith, Sanne A. M. [1 ]
Boss, Marti [1 ]
Brom, Maarten [1 ]
Joosten, Lieke [1 ]
Behe, Martin [2 ]
Buitinga, Mijke [1 ,3 ]
Gotthardt, Martin [1 ]
机构：
[1] Radboudumc, Dept Radiol & Nucl Med, Nijmegen, Netherlands
[2] Paul Scherrer Inst, Ctr Radiopharmaceut Sci ETH PSI USZ, Villigen, Switzerland
[3] Katholieke Univ Leuven, Dept Clin & Expt Med, Leuven, Belgium
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2019年 / 62卷 / 10期
关键词：
exendin-4; GLP-1; receptor; insulinoma; peptide receptor radionuclide therapy (PRRT); positron emission tomography (PET); single-photon emission computed tomography (SPECT); targeted photodynamic therapy (tPDT); theranostics; GLUCAGON-LIKE PEPTIDE-1; GLP-1; RECEPTOR; NEUROENDOCRINE TUMORS; PHOTODYNAMIC THERAPY; GA-68-DOTA-EXENDIN-4; PET/CT; RADIOLABELED PEPTIDES; RADIONUCLIDE THERAPY; CALCIUM STIMULATION; OCCULT INSULINOMA; KIDNEY UPTAKE;
D O I：
10.1002/jlcr.3750
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy.
引用
收藏
页码：656 / 672
页数：17
相关论文
共 100 条
[11]  
Boss M, 2017, NEUROENDOCRINOLOGY, V105, P165
[12]   In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent [J].
Brand, Christian ;
Abdel-Atti, Dalya ;
Zhang, Yachao ;
Carlin, Sean ;
Clardy, Susan M. ;
Keliher, Edmund J. ;
Weber, Wolfgang A. ;
Lewis, Jason S. ;
Reiner, Thomas .
BIOCONJUGATE CHEMISTRY, 2014, 25 (07) :1323-1330
[13]   Radiolabelled GLP-1 analogues for in vivo targeting of insulinomas [J].
Brom, Maarten ;
Joosten, Lieke ;
Oyen, Wim J. G. ;
Gotthardt, Martin ;
Boerman, Otto C. .
CONTRAST MEDIA & MOLECULAR IMAGING, 2012, 7 (02) :160-166
[14]  
Buitinga M, 2018, J NUCL MED
[15]  
Choi IY, 2014, DIABETES, V63, pA259
[16]   Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study [J].
Christ, Emanuel ;
Wild, Damian ;
Ederer, Susanne ;
Behe, Martin ;
Nicolas, Guillaume ;
Caplin, Martyn E. ;
Braendle, Michael ;
Clerici, Thomas ;
Fischli, Stefan ;
Stettler, Christoph ;
Ell, Peter J. ;
Seufert, Jochen ;
Gloor, Beat ;
Perren, Aurel ;
Reubi, Jean Claude ;
Forrer, Flavio .
LANCET DIABETES & ENDOCRINOLOGY, 2013, 1 (02) :115-122
[17]   Glucagon-Like Peptide-1 Receptor Imaging for Localization of Insulinomas [J].
Christ, Emanuel ;
Wild, Damian ;
Forrer, Flavio ;
Braendle, Michael ;
Sahli, Rahel ;
Clerici, Thomas ;
Gloor, Beat ;
Martius, Ferdinand ;
Maecke, Helmut ;
Reubi, Jean Claude .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (11) :4398-4405
[18]   Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT [J].
Chuang, Er-Yuan ;
Giang Thi Ha Nguyen ;
Su, Fang-Yi ;
Lin, Kun-Ju ;
Chen, Chiung-Tong ;
Mi, Fwu-Long ;
Yen, Tzu-Chen ;
Juang, Jyuhn-Huarng ;
Sung, Hsing-Wen .
BIOMATERIALS, 2013, 34 (32) :7994-8001
[19]   Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis [J].
Clardy, Susan M. ;
Keliher, Edmund J. ;
Mohan, James F. ;
Sebas, Matt ;
Benoist, Christophe ;
Mathis, Diane ;
Weissleder, Ralph .
BIOCONJUGATE CHEMISTRY, 2014, 25 (01) :171-177
[20]   Application of Ga68-DOTA-exendin-4 PET/CT to localize an occult insulinoma [J].
Cuthbertson, D. J. ;
Banks, M. ;
Khoo, B. ;
Antwi, K. ;
Christ, E. ;
Campbell, F. ;
Raraty, M. ;
Wild, D. .
CLINICAL ENDOCRINOLOGY, 2016, 84 (05) :789-791
12345678910