Exendin-4 analogs in insulinoma theranostics

被引：55

作者：

Jansen, Tom J. P. ^{[1
]}

van Lith, Sanne A. M. ^{[1
]}

Boss, Marti ^{[1
]}

Brom, Maarten ^{[1
]}

Joosten, Lieke ^{[1
]}

Behe, Martin ^{[2
]}

Buitinga, Mijke ^{[1
,3
]}

Gotthardt, Martin ^{[1
]}

机构：

[1] Radboudumc, Dept Radiol & Nucl Med, Nijmegen, Netherlands

[2] Paul Scherrer Inst, Ctr Radiopharmaceut Sci ETH PSI USZ, Villigen, Switzerland

[3] Katholieke Univ Leuven, Dept Clin & Expt Med, Leuven, Belgium

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2019年 / 62卷 / 10期

关键词：

exendin-4; GLP-1; receptor; insulinoma; peptide receptor radionuclide therapy (PRRT); positron emission tomography (PET); single-photon emission computed tomography (SPECT); targeted photodynamic therapy (tPDT); theranostics; GLUCAGON-LIKE PEPTIDE-1; GLP-1; RECEPTOR; NEUROENDOCRINE TUMORS; PHOTODYNAMIC THERAPY; GA-68-DOTA-EXENDIN-4; PET/CT; RADIOLABELED PEPTIDES; RADIONUCLIDE THERAPY; CALCIUM STIMULATION; OCCULT INSULINOMA; KIDNEY UPTAKE;

D O I：

10.1002/jlcr.3750

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy.

引用

页码：656 / 672

页数：17

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