Synthesis and application of the MCM-41 and SBA-15 as matrices for in vitro efavirenz release study

被引：24

作者：

Jesus, R. A. ^{[1
]}

Rabelo, A. S. ^{[2
]}

Figueiredo, R. T. ^{[2
]}

Cides da Silva, L. C. ^{[3
]}

Codentino, I. C. ^{[4
]}

Fantini, M. C. A. ^{[5
]}

Araujo, G. L. B. ^{[6
]}

Araujo, A. A. S. ^{[2
]}

Mesquita, M. E. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Quim, Ave Marechal Rondon S-N,Cidade Univ, BR-49100000 Sao Cristovao, SE, Brazil

[2] Univ Fed Sergipe, Dept Fisiol, Ave Marechal Rondon S-N,Cidade Univ, BR-49100000 Sao Cristovao, SE, Brazil

[3] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, CP 66083, BR-09500900 Sao Paulo, SP, Brazil

[4] Univ Sao Paulo, Inst Fis, Dept Fis Aplicada, CP 66318, BR-053970 Sao Paulo, SP, Brazil

[5] IPEN, Ave Prof Lineu Prestes 2242, BR-05508900 Sao Paulo, SP, Brazil

[6] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2016年 / 31卷

关键词：

Mesoporous; Controlled release; EFZ; MESOPOROUS SILICA; MOLECULAR-SIEVES; DRUG-DELIVERY; PORE-SIZE; ADSORPTION; COPOLYMER; INHIBITOR; TRIBLOCK; DMP-266; HPLC;

D O I：

10.1016/j.jddst.2015.11.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mesoporous materials in particular the Mobil Composition of Matter No. 41 (MCM-41) and Santa Barbara Amorphous-15 (SBA-15) are considered promising as devices for controlled drug release, because of properties such as hexagonal arrangement, high surface area and non-cytotoxic properties. The materials were synthesized under hydrothermal method and efavirenz (EFZ) was used for testing of controlled release. The material obtained was ordered and had high surface area even after of the incorporation of the drug. The test of the release was made with capsules and the reading was made by UV/Vis with the time interval during two hours to evaluation the efficiency of the dissolution profile of the drug. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：153 / 159

页数：7

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