Hepatosplenic T-cell lymphoma in a patient with Crohn's disease

被引：21

作者：

Beigel, Florian ^{[1
]}

Juergens, Matthias ^{[1
]}

Tillack, Cornelia ^{[1
]}

Subklewe, Marion ^{[2
]}

Mayr, Doris ^{[3
]}

Goeke, Burkhard ^{[1
]}

Brand, Stephan ^{[1
]}

Ochsenkuehn, Thomas ^{[1
]}

机构：

[1] Univ Hosp Munich Grosshadern, Dept Med 2, D-81377 Munich, Germany

[2] Univ Hosp Munich Grosshadern, Dept Med 3, D-81377 Munich, Germany

[3] Univ Hosp Munich Grosshadern, Dept Pathol, D-81377 Munich, Germany

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2009年 / 6卷 / 07期

关键词：

INFLAMMATORY-BOWEL-DISEASE; GAMMA-DELTA; RANDOMIZED-TRIAL; INFLIXIMAB; MAINTENANCE; RISK;

D O I：

10.1038/nrgastro.2009.87

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background. a 58-year-old man who had a 35-year history of Crohn's disease presented to our IBD center with a disease flare, pararectal fistulas and abscess formation. the patient had previously undergone ileocolic resection for a stenosis and his abscesses had been treated by surgical drainage. He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications. Investigations. Physical examination, laboratory investigations including hemoglobin levels and white blood cell counts, genetic testing, CT, bone-marrow biopsy, immunophenotyping by fluorescence-activated cell sorting, polymerase chain reaction analyses, fluorescence in situ hybridization, sputum culture and diagnostic splenectomy. Diagnosis. Hepatosplenic T-cell lymphoma. Management. splenectomy, antibiotic therapy and chemotherapy with cyclophosphamide.

引用

页码：433 / 436

页数：4

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