The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

被引：10
作者：
Ilic-Stojanovic, Snezana S. [1 ]
Nikolic, Vesna D. [1 ]
Nikolic, Ljubisa B. [1 ]
Zdravkovic, Aleksandar S. [2 ]
Kapor, Agnes J. [3 ]
Popsavin, Mirjana M. [4 ]
Petrovic, Slobodan D. [5 ]
机构：
[1] Univ Nis, Fac Technol, Leskovac 16000, Serbia
[2] Coll Text, Leskovac, Serbia
[3] Univ Novi Sad, Fac Sci, Dept Phys, Novi Sad 21000, Serbia
[4] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia
[5] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
来源：
HEMIJSKA INDUSTRIJA | 2015年 / 69卷 / 04期
关键词：
naproxen; photodegradation; 2-hydroxypropyl-beta-cyclodextrin; inclusion complex; HYDROXYPROPYL-BETA-CYCLODEXTRIN; DISSOLUTION; POLY(VINYLPYRROLIDONE); PHOTODEGRADATION; AMLODIPINE; CHITOSAN; SYSTEMS;
D O I：
10.2298/HEMIND131128050I
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-beta cyclodextrin (HP-beta-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-beta-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, H-1 NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-beta-cyclodextrin was photostable for a period of 30 days.
引用
收藏
页码：361 / 370
页数：10
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