The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

被引：10
作者：
Ilic-Stojanovic, Snezana S. [1 ]
Nikolic, Vesna D. [1 ]
Nikolic, Ljubisa B. [1 ]
Zdravkovic, Aleksandar S. [2 ]
Kapor, Agnes J. [3 ]
Popsavin, Mirjana M. [4 ]
Petrovic, Slobodan D. [5 ]
机构：
[1] Univ Nis, Fac Technol, Leskovac 16000, Serbia
[2] Coll Text, Leskovac, Serbia
[3] Univ Novi Sad, Fac Sci, Dept Phys, Novi Sad 21000, Serbia
[4] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia
[5] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
来源：
HEMIJSKA INDUSTRIJA | 2015年 / 69卷 / 04期
关键词：
naproxen; photodegradation; 2-hydroxypropyl-beta-cyclodextrin; inclusion complex; HYDROXYPROPYL-BETA-CYCLODEXTRIN; DISSOLUTION; POLY(VINYLPYRROLIDONE); PHOTODEGRADATION; AMLODIPINE; CHITOSAN; SYSTEMS;
D O I：
10.2298/HEMIND131128050I
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-beta cyclodextrin (HP-beta-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-beta-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, H-1 NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-beta-cyclodextrin was photostable for a period of 30 days.
引用
收藏
页码：361 / 370
页数：10
相关论文
共 50 条
  • [31] The interaction between phenolphthalein and 2-hydroxypropyl-β-cyclodextrin:: on the determination of the formation constants of cyclodextrin inclusion complexes
    Buvari-Barcza, A
    Barcza, L
    ANALES DE QUIMICA-INTERNATIONAL EDITION, 1998, 94 (02): : 98 - 100
  • [32] Study of the solubility, photostability and structure of inclusion complexes of carvedilol with β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin
    Ivana Savic-Gajic
    Ivan M. Savic
    Vesna D. Nikolic
    Ljubisa B. Nikolic
    Mirjana M. Popsavin
    Agnes J. Kapor
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2016, 86 : 7 - 17
  • [33] Inclusion Complex of Carprofen with Hydroxypropyl-β-cyclodextrin
    Fu-An Chen
    An-Bang Wu
    Chau-Yang Chen
    Journal of inclusion phenomena and macrocyclic chemistry, 2003, 46 : 111 - 115
  • [34] Preparation and characterization of the inclusion complex of hypocrellin A with hydroxypropyl-β-cyclodextrin
    Su, Yujie
    Rao, Shengqi
    Cai, Yujie
    Yang, Yanjun
    EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2010, 231 (05) : 781 - 788
  • [35] Naproxen: Hydroxypropyl-β-Cyclodextrin:Polyvinylpyrrolidone Ternary Complex Formation
    Margarita Valero
    Brígida Esteban
    Rafael Peläez
    Licesio J. Rodrïguez
    Journal of inclusion phenomena and macrocyclic chemistry, 2004, 48 : 157 - 163
  • [36] Preparation and characterization of inclusion complex of Myristica fragrans Houtt. (nutmeg) essential oil with 2-hydroxypropyl-β-cyclodextrin
    Xi, Xiaohui
    Huang, Jialing
    Zhang, Shengyang
    Lu, Qian
    Fang, Zhengfeng
    Li, Cheng
    Zhang, Qing
    Liu, Yuntao
    Chen, Hong
    Liu, Aiping
    Liu, Shuxiang
    Wang, Caixia
    Li, Shanshan
    Hu, Bin
    FOOD CHEMISTRY, 2023, 423
  • [37] Impact of 2-hydroxypropyl-β-cyclodextrin inclusion complex formation on dopamine receptor-ligand interaction - A case study
    Zell, Lukas
    Hofer, Thomas S.
    Schubert, Mario
    Popoff, Alexander
    Hoell, Anna
    Marschhofer, Moritz
    Huber-Cantonati, Petra
    Temml, Veronika
    Schuster, Daniela
    BIOCHEMICAL PHARMACOLOGY, 2024, 226
  • [38] Inclusion Complexation of Indomethacin with Hydroxypropyl-β-cyclodextrin
    Manosroi, Jiradej
    Chankhampan, Charinya
    Foe, Kuncoro
    Apriyani, Maria Goretti
    Manosroi, Worapaka
    Manosroi, Aranya
    CHIANG MAI JOURNAL OF SCIENCE, 2016, 43 (03): : 631 - 642
  • [39] Inclusion complexes of fluconazole with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin in aqueous solution: preparation, characterization and a structural insight
    Jing Li
    Shuo Zhang
    Yan Zhou
    Su Guan
    Lei Zhang
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2016, 84 : 209 - 217
  • [40] Synthesis and characterization of praseodymium-2-hydroxypropyl--cyclodextrin inclusion complex
    Lopez-Gonzalez, Hilario
    Moreno-Cruz, Erick
    Rojas-Hernandez, Alberto
    Jimenez Becerril, Jaime
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2019, 319 (03) : 837 - 845
12345