The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

被引：10
|
作者：
Ilic-Stojanovic, Snezana S. [1 ]
Nikolic, Vesna D. [1 ]
Nikolic, Ljubisa B. [1 ]
Zdravkovic, Aleksandar S. [2 ]
Kapor, Agnes J. [3 ]
Popsavin, Mirjana M. [4 ]
Petrovic, Slobodan D. [5 ]
机构：
[1] Univ Nis, Fac Technol, Leskovac 16000, Serbia
[2] Coll Text, Leskovac, Serbia
[3] Univ Novi Sad, Fac Sci, Dept Phys, Novi Sad 21000, Serbia
[4] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia
[5] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
来源：
HEMIJSKA INDUSTRIJA | 2015年 / 69卷 / 04期
关键词：
naproxen; photodegradation; 2-hydroxypropyl-beta-cyclodextrin; inclusion complex; HYDROXYPROPYL-BETA-CYCLODEXTRIN; DISSOLUTION; POLY(VINYLPYRROLIDONE); PHOTODEGRADATION; AMLODIPINE; CHITOSAN; SYSTEMS;
D O I：
10.2298/HEMIND131128050I
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-beta cyclodextrin (HP-beta-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-beta-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, H-1 NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-beta-cyclodextrin was photostable for a period of 30 days.
引用
收藏
页码：361 / 370
页数：10
相关论文
共 50 条
  • [11] Characterization and in vivo evaluation of an inclusion complex of oridonin and 2-hydroxypropyl-β-cyclodextrin
    Yan, Zhiqiang
    Xu, Wen
    Sun, Jin
    Liu, Xiaohong
    Zhao, Yanping
    Sun, Yinghua
    Zhang, Tianhong
    He, Zhonggui
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2008, 34 (06) : 632 - 641
  • [12] Preparation and characterization of spiro-acridine derivative and 2-hydroxypropyl-β-cyclodextrin inclusion complex
    Melo, Camila de Oliveira
    da Silva Rodrigues, Maria Salete
    Santos da Silva, Marcus Vinicius
    Marcelino, Henrique Rodrigues
    Rabello, Marcelo Montenegro
    de Moura, Ricardo Olimpio
    Oliveira, Elquio Eleamen
    JOURNAL OF MOLECULAR STRUCTURE, 2020, 1222 (1222)
  • [13] Piroxicam/2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex Prepared by a New Fluid-Bed Coating Technique
    Zhang, Xingwang
    Wu, Danni
    Lai, Jie
    Lu, Yi
    Yin, Zongning
    Wu, Wei
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (02) : 665 - 675
  • [14] Preparation of inclusion complex of praziquantel with 2-hydroxypropyl-β-cyclodextrin and pharmacokinetic property improvement
    Ding, Yili
    Cui, Wutong
    Pang, Yuchang
    Prasad, Chamakura V. N. S. Vara
    Wang, Bingyun
    ARABIAN JOURNAL OF CHEMISTRY, 2021, 14 (09)
  • [15] A molecular inclusion complex of atenolol with 2-hydroxypropyl-β-cyclodextrin;: the production and characterization thereof
    Nikolic, Vesna
    Nikolic, Ljubisa
    Stankovic, Mihajlo
    Kapor, Agnes
    Popsavin, Mirjana
    Cvetkovic, Dragan
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2007, 72 (8-9) : 737 - 746
  • [16] Inclusion complexes of fluconazole with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin in aqueous solution: preparation, characterization and a structural insight
    Li, Jing
    Zhang, Shuo
    Zhou, Yan
    Guan, Su
    Zhang, Lei
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2016, 84 (3-4) : 209 - 217
  • [17] Comprehensive Physico-Chemical Characterization of a Serotonin Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin
    Fateminasab, F.
    Bordbar, A. K.
    Shityakov, S.
    Saboury, A. A.
    JOURNAL OF SOLUTION CHEMISTRY, 2020, 49 (7-8) : 915 - 944
  • [18] Inclusion complex of ITH12674 with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization and pharmacological effect
    Michalska, Patrycja
    Wojnicz, Aneta
    Ruiz-Nuno, Ana
    Abril, Sheila
    Buendia, Izaskun
    Leon, Rafael
    CARBOHYDRATE POLYMERS, 2017, 157 : 94 - 104
  • [19] Study of the solubility, photostability and structure of inclusion complexes of carvedilol with β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin
    Savic-Gajic, Ivana
    Savic, Ivan M.
    Nikolic, Vesna D.
    Nikolic, Ljubisa B.
    Popsavin, Mirjana M.
    Kapor, Agnes J.
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2016, 86 (1-2) : 7 - 17
  • [20] Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone
    Creteanu, Andreea
    Pamfil, Daniela
    Vasile, Cornelia
    Tantaru, Gladiola
    Ghiciuc, Cristina Mihaela
    Ochiuz, Lacramioara
    Ghilan, Alina
    Macsim, Ana Maria
    INTERNATIONAL JOURNAL OF POLYMER SCIENCE, 2019, 2019
12345