The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

被引：28

作者：

Liberini, Virginia ^{[1
,2
]}

Huellner, Martin W. ^{[2
]}

Grimaldi, Serena ^{[1
]}

Finessi, Monica ^{[1
]}

Thuillier, Philippe ^{[1
,3
]}

Muni, Alfredo ^{[4
]}

Pellerito, Riccardo E. ^{[5
]}

Papotti, Mauro G. ^{[6
,7
]}

Piovesan, Alessandro ^{[8
]}

Arvat, Emanuela ^{[9
]}

Deandreis, Desiree ^{[1
]}

机构：

[1] Univ Turin, Dept Med Sci, Nucl Med Unit, I-10126 Turin, Italy

[2] Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, CH-8091 Zurich, Switzerland

[3] Univ Hosp Brest, Dept Endocrinol, F-29200 Brest, France

[4] SS Biagio & Antonio & C Arrigo Hosp, Dept Nucl Med, I-15121 Alessandria, Italy

[5] AO Ordine Mauriziano Torino, Dept Nucl Med, I-10128 Turin, Italy

[6] City Hlth & Sci Univ Hosp, Pathol Unit, I-10126 Turin, Italy

[7] Univ Turin, Molinette Hosp, Dept Oncol, I-10126 Turin, Italy

[8] AOU Citta Salute Sci Turin, Dept Endocrinol, I-10126 Turin, Italy

[9] Univ Turin, Dept Med Sci, Oncol Endocrinol, I-10126 Turin, Italy

来源：

DIAGNOSTICS | 2020年 / 10卷 / 12期

关键词：

peptide receptor radionuclide therapy; PRRT; Ga-68-labeled somatostatin analogue; F-18-FDG; response assessment; RECIST; SWOG; WHO; neuroendocrine tumors; NET; POSITRON-EMISSION-TOMOGRAPHY; QUALITY-OF-LIFE; CHROMOGRANIN-A; VOLUMETRIC PARAMETERS; PROCEDURE GUIDELINES; COMPUTED-TOMOGRAPHY; SINGLE-INSTITUTION; TYR(3) OCTREOTATE; MULTIDETECTOR CT; LIVER METASTASES;

D O I：

10.3390/diagnostics10121083

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT response assessment is challenging and no consensus on methods and timing has yet been reached among experts in the field. This issue is owed to the suboptimal sensitivity and specificity of clinical biomarkers, limitations of morphological response criteria in slowly growing tumors and necrotic changes after therapy, a lack of standardized parameters and timing of functional imaging and the heterogeneity of PRRT protocols in the literature. The aim of this article is to review the most relevant current approaches for PRRT efficacy prediction and response assessment criteria in order to provide an overview of suitable tools for safe and efficacious PRRT.

引用

页数：31

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