Tramtrack co-operates to prevent inappropriate neural development in Drosophila

被引：36

作者：

Badenhorst, P ^{[1
]}

Finch, JT ^{[1
]}

Travers, AA ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 117卷 / 1-2期

关键词：

tramtrack; BTB domain; Drosophila; neurogenesis; peripheral nervous system; Achaete-Scute complex;

D O I：

10.1016/S0925-4773(02)00183-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories defined by expression of the proneural genes of the Achaete-Scute complex (AS-C). Formation of ectopic sensilla outside these regions is prevented by transcriptional repression of proneural genes. We demonstrate that the BTB/POZ-domain transcriptional repressor Tramtrack (Ttk) co-operates in this repression. Ttk is expressed ubiquitously, except in proneural clusters and SOPs. Ttk over-expression represses proneural genes and sensilla formation. Loss of Ttk enhances bristle-promoting mutants. Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-a-brac-tramtrack-broad complex (BTB) motif. We show that the Ttk BTB domain is a protein-protein interaction motif mediating tetramer formation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：87 / 101

页数：15

共 65 条

[1] Crystal structure of the BTB domain from PLZF [J].