Antioxidants and human diseases

被引：360

作者：

Rajendran, Peramaiyan ^{[1
]}

Nandakumar, Natarajan ^{[2
]}

Rengarajan, Thamaraiselvan ^{[1
]}

Palaniswami, Rajendran ^{[4
]}

Gnanadhas, Edwinoliver Nesamony ^{[5
]}

Lakshminarasaiah, Uppalapati ^{[6
]}

Gopas, Jacob ^{[2
,3
]}

Nishigaki, Ikuo ^{[1
]}

机构：

[1] NPO, Int Lab Biochem, Nakagawa Ku, 1-166 Uchide, Nagoya, Aichi 4540926, Japan

[2] Ben Gurion Univ Negev, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel

[3] Soroka Univ, Med Ctr, Dept Oncol, IL-84105 Beer Sheva, Israel

[4] Madurai Kamaraj Univ, Vivekananda Coll, A Gurukula Inst Life Training, Dept Appl Zool & Biotechnol, Madurai 625234, Tamil Nadu, India

[5] Ben Gurion Univ Negev, Avram & Stella Goldstein Goren Dept Biotechnol En, IL-84105 Beer Sheva, Israel

[6] Ben Gurion Univ Negev, Soroka Univ, Med Ctr, Dept Clin Biochem & Pharmacol, IL-84105 Beer Sheva, Israel

来源：

CLINICA CHIMICA ACTA | 2014年 / 436卷

关键词：

Antioxidant; Oxidative stress; Diabetes; Cancer; OXIDATION PROTEIN PRODUCTS; NF-KAPPA-B; EXTRACELLULAR-SUPEROXIDE DISMUTASE; XENOBIOTIC-METABOLIZING ENZYMES; LOW-DENSITY-LIPOPROTEIN; DIETARY VITAMIN-E; DNA-DAMAGE; LIPID-PEROXIDATION; ASCORBIC-ACID; FREE-RADICALS;

D O I：

10.1016/j.cca.2014.06.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Oxidative stress plays a pivotal role in the development of human diseases. Reactive oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide anion, singlet oxygen, lipid peroxides, hypochlorite and hydroxyl radical are involved in growth, differentiation, progression and death of the cell. They can react with membrane lipids, nucleic adds, proteins, enzymes and other small molecules. Low concentrations of ROS has an indispensable role in intracellular signalling and defence against pathogens, while, higher amounts of ROS play a role in number of human diseases, including arthritis, cancer, diabetes, atherosclerosis, ischemia, failures in immunity and endocrine functions. Antioxidants presumably act as safeguard against the accumulation of ROS and their elimination from the system. The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：332 / 347

页数：16

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