Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

被引：38

作者：

Yu, Lu ^{[1
]}

Somfai, Peter ^{[1
]}

机构：

[1] Lund Univ, Dept Chem, Ctr Anal & Synth, S-22100 Lund, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 25期

基金：

瑞典研究理事会;

关键词：

amines; copper; enamines; enantioselectivity; hydroamination; ANTI-MARKOVNIKOV HYDROAMINATION; CATALYTIC ASYMMETRIC DIAMINATION; METAL-FREE DIAMINATION; INTERMOLECULAR HYDROAMINATION; UNACTIVATED ALKENES; VICINAL DIAMINES; AMINES; AMINOBORATION; PALLADIUM; VINYLARENES;

D O I：

10.1002/anie.201902642

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

引用

页码：8551 / 8555

页数：5

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