500-element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls

被引:265
作者
Hynynen, K
Clement, GT
McDannold, N
Vykhodtseva, N
King, R
White, PJ
Vitek, S
Jolesz, FA
机构
[1] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] InSightec Ltd, Tirat Carmel, Israel
关键词
MRI; minimally invasive surgery; brain; focused ultrasound; tissue ablation;
D O I
10.1002/mrm.20118
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The aim of this study was to test a prototype MRI-compatible focused ultrasound phased array system for trans-skull brain tissue ablation. Rabbit thigh muscle and brain were sonicated with a prototype, hemispherical 500-element ultrasound phased array operating at frequencies of 700-806 kHz. An ex vivo human skull sample was placed between the array and the animal tissue. The temperature elevation during 20-30-sec sonications was monitored using MRI thermometry. The induced focal lesions were observed in T-2 and contrast-enhanced T-1-weighted fast spin echo images. Whole brain histology evaluation was performed after the sonications. The results showed that sharp temperature elevations can be produced both in the thigh muscle and in the brain. High-power sonications (600-1080 W) produced peak temperatures up to 55degreesC and focal lesions that were consistent with thermal tissue damage. The lesion size was found to increase with increasing peak temperature. The device was then modified to operate in the orientation that will be used in the clinic and successfully tested in phantom experiments. As a conclusion, this study demonstrates that it is possible to create ultrasound-induced lesions in vivo through a human skull under MRI guidance with this large-scale phased array. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:100 / 107
页数:8
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