Binding behaviors of scutellarin with α-, β-, γ-cyclodextrins and their derivatives

被引：30

作者：

Yang, Bo ^{[1
,2
]}

Yang, Li-Juan ^{[1
]}

Lin, Jun ^{[1
]}

Chen, Yong ^{[2
]}

Liu, Yu ^{[2
]}

机构：

[1] Yunnan Univ, Sch Chem, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China

[2] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2009年 / 64卷 / 1-2期

关键词：

Scutellarin; Cyclodextrin; Inclusion complexation; Supramolecular chemistry; INCLUSION COMPLEXES; SOLUBILIZATION;

D O I：

10.1007/s10847-009-9547-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of cyclodextrin/scutellarin inclusion complexes were prepared from alpha-cyclodextrin, beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin with scutellarin (SCU), and their inclusion complexation behaviors, such as stoichiometry, complex stability constants and inclusion mode, were investigated by means of UV/Vis spectroscopy, H-1 NMR and 2D NMR. The results showed that the SCU could be efficiently encapsulated in the cyclodextrin cavity in aqueous solution to produce complexes that were more soluble than free SCU. The enhanced binding ability of cyclodextrins towards SCU was discussed from the viewpoint of the size/shape-fit and multiple recognition mechanism between host and guest.

引用

页码：149 / 155

页数：7

共 25 条

[1]

[Anonymous], 2002, J PHARM PRACT

[2]

[Anonymous], 1998, CHINESE PHARMACOL B

[3]

[Anonymous], 2006, CHIN J CLIN PHARM TH

[4] Study of inclusion complexes of acridine with β- and (2,6-di-O-methyl)-β-cyclodextrin by use of solubility diagrams and NMR spectroscopy [J].

Correia, I ;

Bezzenine, N ;

Ronzani, N ;

Platzer, N ;

Beloeil, JC ;

Doan, BT .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2002, 15 (09) :647-659

[5]

Deng T.F., 2002, CHINA PHARM, V11, P728

[6] Sulfadiazine/hydroxypropyl-β-cyclodextrin host-guest system:: Characterization, phase-solubility and molecular modeling [J].

Gaspar de Araujo, Marcia Valeria ;

Barbosa Vieira, Elze Kelly ;

Lazaro, Gilderman Silva ;

Conegero, Leila Souza ;

Almeida, Luis Eduardo ;

Barreto, Ledjane Silva ;

da Costa, Nivan Bezerra, Jr. ;

Gimenez, Iara F. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (10) :5788-5794

[7]

[葛庆华 Ge Qinghua], 2003, [中国医药工业杂志, Chinese Journal of Pharmaceuticals], V34, P618

[8] Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin [J].

Hong, H ;

Liu, GQ .

LIFE SCIENCES, 2004, 74 (24) :2959-2973

[9] Inclusion complexation of (cyclo)alkanes and (cyclo)alkanols with 6-O-modified cyclodextrins [J].

Inoue, Y ;

Yamamoto, K ;

Wada, T ;

Everitt, S ;

Gao, XM ;

Hou, ZJ ;

Tong, LH ;

Jiang, SK ;

Wu, HM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1998, (08) :1807-1816

[10]

Jiang Xue-hua, 2003, Yaoxue Xuebao, V38, P371

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