HopW1 from Pseudomonas syringae Disrupts the Actin Cytoskeleton to Promote Virulence in Arabidopsis

被引：80

作者：

Kang, Yongsung ^{[1
]}

Jelenska, Joanna ^{[1
]}

Cecchini, Nicolas M. ^{[1
]}

Li, Yujie ^{[1
]}

Lee, Min Woo ^{[1
]}

Kovar, David R. ^{[1
]}

Greenberg, Jean T. ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

PLOS PATHOGENS | 2014年 / 10卷 / 06期

基金：

美国国家科学基金会;

关键词：

BINDING PROTEINS; CAPPING PROTEIN; RECEPTOR FLS2; PLANT; EFFECTOR; COMPLEX; ENDOCYTOSIS; STRATEGIES; DYNAMICS; TRAFFICKING;

D O I：

10.1371/journal.ppat.1004232

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A central mechanism of virulence of extracellular bacterial pathogens is the injection into host cells of effector proteins that modify host cellular functions. HopW1 is an effector injected by the type III secretion system that increases the growth of the plant pathogen Pseudomonas syringae on the Columbia accession of Arabidopsis. When delivered by P. syringae into plant cells, HopW1 causes a reduction in the filamentous actin (F-actin) network and the inhibition of endocytosis, a known actin-dependent process. When directly produced in plants, HopW1 forms complexes with actin, disrupts the actin cytoskeleton and inhibits endocytosis as well as the trafficking of certain proteins to vacuoles. The C-terminal region of HopW1 can reduce the length of actin filaments and therefore solubilize F-actin in vitro. Thus, HopW1 acts by disrupting the actin cytoskeleton and the cell biological processes that depend on actin, which in turn are needed for restricting P. syringae growth in Arabidopsis.

引用

页数：10

共 52 条

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