EFFICIENT SYNTHESIS OF 2-ALKYLIDENE-4H-3,1-BENZOXATHIIN-4-ONES AND DETERMINATION OF THEIR DOUBLE BOND CONFIGURATION

被引：5

作者：

Shimizu, Masao ^{[1
]}

Yamanaka, Masaki ^{[2
]}

Ando, Wataru ^{[1
]}

Shimada, Shigeru ^{[1
]}

Konakahara, Takeo ^{[2
]}

Sakai, Norio ^{[2
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan

[2] Tokyo Univ Sci, Fac Sci & Technol, Dept Ind Chem, Noda, Chiba 2788510, Japan

来源：

HETEROCYCLES | 2014年 / 89卷 / 04期

关键词：

ASPIRIN PRODRUGS; 2-CHLORO-1,3-DIMETHYLIMIDAZOLINIUM CHLORIDE; CONDENSING AGENT; HYDROLYSIS; ESTERS; AMIDES; ACIDS;

D O I：

10.3987/COM-14-12943

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Alkylidene-4H-3,1-benzoxathiin-4-ones were efficiently synthesized by reaction of 2-(acylthio)benzoic acids with condensation reagents in the presence of base. The E and Z isomers of the products were distinguished by comparison of the chemical shifts of the vinylic protons in the H-1 NMR spectra of the 4H-3,1-benzoxathiin-4-ones and their corresponding 1-oxides.

引用

页码：981 / 993

页数：13

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