Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment

被引：155

作者：

Cai, Fengfeng ^{[1
]}

Luis, Manuel Antonio Falar ^{[1
]}

Lin, Xiaoyan ^{[1
]}

Wang, Minghong ^{[2
,3
]}

Cai, Lu ^{[1
]}

Cen, Chunmei ^{[1
]}

Biskup, Ewelina ^{[4
]}

机构：

[1] Tongji Univ, Sch Med, Yangpu Hosp, Dept Breast Surg, 450 Tengyue Rd, Shanghai 200090, Peoples R China

[2] Tongji Univ, Sch Med, Yangpu Hosp, Dept Gen Practice, 450 Tengyue Rd, Shanghai 200090, Peoples R China

[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Cardiol, Shanghai 200438, Peoples R China

[4] Shanghai Univ Med & Hlth Sci, Dept Basic Med Sci, Shanghai 201318, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2019年 / 11卷 / 01期

基金：

芬兰科学院; 上海市自然科学基金;

关键词：

anthracyclines; breast cancer; doxorubicin; cardiotoxicity; risk factors; prevention; treatment; DOXORUBICIN-INDUCED CARDIOTOXICITY; CONGESTIVE-HEART-FAILURE; CARDIAC TROPONIN-T; CARDIOVASCULAR-DISEASE; MOLECULAR-BASIS; RISK-FACTORS; THERAPY; TOXICITY; ECHOCARDIOGRAPHY; INHIBITION;

D O I：

10.3892/mco.2019.1854

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline-induced cardiotoxicity. The objective of this paper was to provide a review of the clinical classification, risk factors, monitoring and prevention of anthracycline-induced cardiotoxicity in patients with breast cancer.

引用

页码：15 / 23

页数：9

共 61 条

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