The catalytic mechanisms of binuclear metallohydrolases

被引：401
作者：
Mitic, Natasa
Smith, Sarah J.
Neves, Ademir
Guddat, Luke W.
Gahan, Lawrence R.
Schenk, Gerhard [1 ]
机构：
[1] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
来源：
CHEMICAL REVIEWS | 2006年 / 106卷 / 08期
关键词：
D O I：
10.1021/cr050318f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
With the aim of critically assessing the current models for metal ion assisted hydrolytic reaction mechanisms, an updated review of the current understanding of metallohydrolase-catalyzed reactions is presented. Focus is on four systems, purple acid phosphatases (PAPs), Ser/Thr protein phosphatases (PPs), 3′-5′ exonucleases, and 5′-nucleotidases (5′-NTs), which have contributed to major advancement of the understanding of the catalytic mechanisms that operate in such enzymes.
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收藏
页码：3338 / 3363
页数：26
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