Gemcitabine-based Adjuvant Chemotherapy for Patients with Advanced Gallbladder Cancer

被引：0
作者：
Nakamura, Masafumi [1 ]
Nakashima, Hiroshi [1 ]
Abe, Toshiya [1 ]
Ensako, Takaaki [1 ]
Yoshida, Koji [2 ]
Hino, Keisuke [2 ]
机构：
[1] Kawasaki Med Sch, Dept Digest Surg, Kurashiki, Okayama 7010192, Japan
[2] Kawasaki Med Sch, Dept Hepatol & Pancreatol, Kurashiki, Okayama 7010192, Japan
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 06期
关键词：
Gallbladder cancer; curability; gemcitabine (GEM); adjuvant chemotherapy; BILIARY-TRACT CANCER; CONCURRENT CHEMORADIATION; IMPROVES SURVIVAL; PHASE-III; PLUS S-1; RADIOTHERAPY; COMBINATION; MULTICENTER; CISPLATIN; RESECTION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We investigated effects of gemcitabine-based adjuvant chemotherapy (GEM) on prognosis of patients with gallbladder cancer. Patients and Methods: We retrospectively analyzed outcomes of 36 patients who underwent radical resection for gallbladder cancer from 2001 through to 2012, using chi(2) for prognostic factors and Kaplan-Meier estimator and log-rank tests for survival data. Results: The GEM group had higher rates of lymph node positivity and distant metastasis, higher UICC stage and fewer R0 resections; their 5-year survival rate (60%) did not significantly differ from that of the controls (70.0%), nor was GEM a significant prognostic factor in univariate analysis. However, among patients who underwent R1 and R2 resections, GEM significantly improved prognosis in both univariate and multivariate analyses. Median survival of the R1/2 GEM group (66.4 months) was significantly better than that of controls (5.4 months) (p=0.002). Conclusion: GEM improved prognosis of patients with gallbladder cancer after R1/R2 resections.
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页码：3125 / 3129
页数：5
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