Synthesis of some novel 4-substituted coumarins having potential biological activity (Part III)

被引：0

作者：

Mashelkar, U. C. ^{[1
]}

Audi, A. A. ^{[1
]}

机构：

[1] SS & LS Patkar Coll, Organ Res Lab, Bombay 400062, Maharashtra, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2006年 / 45卷 / 06期

关键词：

Schiff bases; thioglycolic acid 4-thiazolidinone; oxadiazoles and thiadiazoles; polyphosphoric acid;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various methyl substituted coumarin carboxaldehydes haw been condensed with aromatic amines to give Schiff bases. These Schiff bases have then been reacted with thioglycolic acid to give five membered cyclized products, 4-thiazolidinone substituted at 4-position of coumarins. 4-alkyl coumarin acetates have been reacted with semicarbazide or thiosemicarbazide in polyphosphoric acid to undergo condensation followed by in situ cyclization to form oxadiazoles and thiadiazoles. All the 4 - substituted coumarin heterocycles have been found to possess antibacterial activity.

引用

页码：1463 / 1469

页数：7

共 40 条

[1] Synthesis and Spectral Study of Some New 4-substituted but-2-enolide Derivatives [J].

Altaee, Enas A. ;

Al-Sabawi, Ammar H. .

EGYPTIAN JOURNAL OF CHEMISTRY, 2021, 64 (12) :7017-7022

[2] Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer's disease [J].

Ali, Saima ;

Siddiqui, Sabahat Zahra ;

Khan, Khalid Mohammed ;

Abbasi, Muhammad Athar ;

Aziz-ur-Rehman ;

Saad, Syed Muhammad ;

Shah, Syed Adnan Ali ;

Saleem, Rahman Shah Zaib ;

Ashraf, Muhammad .

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2022, 19 (11) :4491-4502

[3] Synthesis, Characterisation and Cardiac Activity of Some Novel 2,3-Substituted-4-phenyl-1,3-oxazolidine Derivatives [J].

Gudaprthi, Vijayalakshmi ;

Bharathi, K. ;

Omprakash, G. .

ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (02) :765-769

[4] Synthesis, Docking and Antimicrobial Activity Studies of Some Novel Fused Thiophenes of Biological Interest [J].

Ramalingam, Anitha ;

Sarvanan, Janardhanan .

JOURNAL OF YOUNG PHARMACISTS, 2020, 12 (02) :118-124

[5] Synthesis and biological evaluation of some new N4-substituted isatin-3-thiosemicarbazones [J].

Pervez, Humayun ;

Chohan, Zahid Hussain ;

Ramzan, Muhammad ;

Nasim, Faiz-Ul-Hassan ;

Khan, Khalid Mohammed .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2009, 24 (02) :437-446

[6] Synthesis, Characterization, Biological Activity, and Thermal Stability of New Styrenic Polymer Having Pendant Ketone and Its Some Derivatives [J].

Erol, Ibrahim ;

Sahin, Zehra ;

Ozcan, Levent .

POLYMER ENGINEERING AND SCIENCE, 2013, 53 (07) :1383-1393

[7] Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity [J].

Abdel-Aziz, Hatem A. ;

Aboul-Fadl, Tarek ;

Al-Obaid, Abdul-Rahman M. ;

Ghazzali, Mohamed ;

Al-Dhfyan, Abdullah ;

Contini, Alessandro .

ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (09) :1543-1552

[8] Synthesis and Biological Activity of Some 2-(2′-(Substituted Phenyl-4-thiazolidinone-3-yl)-1′3′-isoxazol-4-yl)aminoquinoline Derivatives [J].

Ahirwar, Mukesh Kumar ;

Shrivastava, S. P. .

E-JOURNAL OF CHEMISTRY, 2011, 8 (02) :931-937

[9] Microwave Assisted Synthesis and Biological Activity of Novel Bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} Derivatives [J].

Baba, N. H. Kumar ;

Ashok, D. ;

Rao, Boddu Ananda ;

Sarasija, Madderla ;

Murthy, N. Y. S. .

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (03) :580-586

[10] Synthesis and Antibacterial Activity of 3-Chloro-1-[(2-hydroxynaphthalen-1-yl)(substituted phenyl)methyl]-4-substituted Phenylazetidin-2-ones Under Microwave Irradiation [J].

Tiwari, Vandana ;

Ali, Parvez ;

Meshram, Jyotsna .

JORDAN JOURNAL OF CHEMISTRY, 2010, 5 (04) :331-341

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