Pharmacokinetics and bioavailability of cinnamic acid after oral administration of ramulus cinnamomi in rats

被引：53
作者：
Chen, Yingrong [1 ]
Ma, Yueming [1 ,2 ]
Ma, Wei [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Pharmacokinet Lab, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Ctr Tradit Chinese Med & Syst Biol, Shanghai 201203, Peoples R China
来源：
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2009年 / 34卷 / 01期
关键词：
Ramulus Cinnamomi; cinnamic acid; cinnamaldehyde; pharmacokinetics; bioavailability;
D O I：
10.1007/BF03191384
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetics of cinnamic acid (CA) after oral administration of Decoction of Ramulus Cinnamomi (RC) 7.4 g/kg [containing CA 7.62x10(-5) mol/kg and cinnamaldehyde (CNMA) 1.77x 10(-5) mol/kg], was compared with that after oral administration of pure CA 7.62x10(-5) mol/kg in rats. Plasma concentrations of CA and hippuric acid (HA) were determined by HPLC. Pharmacokinetic parameters were calculated from the plasma concentration-time data. CA was quickly absorbed and then metabolized mainly into HA. The AUC((0-1)) and AUC((0-infinity)) of CA were higher in RC group than those in pure CA group and the bioavailability of CA from RC was higher than that from pure CA. After ig administration of 3.79x10(-4) mol/kg, CNMA was at least partially metabolized into CA in stomach and small intestine and almost completely metabolized into CA in liver before it is absorbed into blood in rats. The results showed that plasma CA in RC group might partly come from transformation of CNMA in RC.
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收藏
页码：51 / 56
页数：6
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