Molecular mechanisms of prostate cancer

被引：64

作者：

Porkka, KP

Visakorpi, T

机构：

[1] Tampere Univ, Inst Med Technol, Canc Genet Lab, FIN-33520 Tampere, Finland

[2] Tampere Univ Hosp, FIN-33520 Tampere, Finland

来源：

EUROPEAN UROLOGY | 2004年 / 45卷 / 06期

基金：

芬兰科学院;

关键词：

prostate cancer; genetics; oncogene; tumor suppressor gene; susceptibility;

D O I：

10.1016/j.eururo.2004.01.012

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

During the last ten years our knowledge of genetic alterations in prostate cancer has significantly increased. For example, several chromosomal loci possibly harboring predisposing or somatically mutated genes have been suggested. Still, we lack the comprehensive molecular model for the development and progression of prostate cancer. Only a few genes have been found to be aberrated in a significant proportion of prostate cancer. These include GSTP1, PTEN, TP53, and AR. Thus, they are natural targets for new treatment strategies. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：683 / 691

页数：9

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