Solubility of flurbiprofen in supercritical carbon dioxide

被引：87
|
作者：
Duarte, ARC
Coimbra, P
de Sousa, HC
Duarte, CMM
机构：
[1] Inst Biol Expt & Tecnol, P-2780 Oeiras, Portugal
[2] Univ Coimbra, Dept Engn Quim, FCT, P-3030290 Coimbra, Portugal
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2004年 / 49卷 / 03期
关键词：
D O I：
10.1021/je034099b
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.
引用
收藏
页码：449 / 452
页数：4
相关论文
共 50 条
  • [41] SOLUBILITY OF MENTHOL IN SUPERCRITICAL CARBON-DIOXIDE
    SOVOVA, H
    JEZ, J
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1994, 39 (04): : 840 - 841
  • [42] Solubility of azelaic acid in supercritical carbon dioxide
    Sparks, Darrell L.
    Hernandez, Rafael
    Estevez, L. Antonio
    Meyer, Nicholas
    French, Todd
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2007, 52 (04): : 1246 - 1249
  • [43] Solubility of iodopropynyl butylcarbamate in supercritical carbon dioxide
    Shin, Moon Sam
    Kim, Hwayong
    FLUID PHASE EQUILIBRIA, 2008, 270 (1-2) : 45 - 49
  • [44] RDX's solubility in supercritical carbon dioxide
    Department of Environmental and Safety Engineering, North University of China, Taiyuan 030051, China
    Hanneng Cailiao, 2006, 3 (178-180):
  • [45] Solubility determination of α-asarone in supercritical carbon dioxide
    Chen, X.Q.
    Zhao, T.S.
    Li, Y.X.
    Yu, W.
    Huaxue Gongcheng/Chemical Engineering (China), 2001, 29 (03):
  • [46] Solubility measurement of α-asarone in supercritical carbon dioxide
    Chen, XQ
    Zhao, TS
    Yu, W
    FLUID PHASE EQUILIBRIA, 2003, 211 (01) : 11 - 15
  • [47] SOLUBILITY OF CHOLESTEROL IN SUPERCRITICAL CARBON-DIOXIDE
    YUN, SLJ
    LIONG, KK
    GURDIAL, GS
    FOSTER, NR
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1991, 30 (11) : 2476 - 2482
  • [48] Solubility of mixed solids in supercritical carbon dioxide
    Tian, Guohua
    Jin, Junsu
    Zhang, Zeting
    Guo, Jianjian
    FLUID PHASE EQUILIBRIA, 2007, 251 (01) : 47 - 51
  • [49] Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide
    Chim, Rita
    Marceneiro, Sofia
    Braga, Mara E. M.
    Dias, Ana M. A.
    de Sousa, Herminio C.
    FLUID PHASE EQUILIBRIA, 2012, 331 : 6 - 11
  • [50] Solubility of pharmaceutical compounds in supercritical carbon dioxide
    De Zordi, N.
    Kikic, I.
    Moneghini, M.
    Solinas, D.
    JOURNAL OF SUPERCRITICAL FLUIDS, 2012, 66 : 16 - 22
12345