The search for physiological substrates of MAP and SAP kinases in mammalian cells

被引：513
作者：
Cohen, P
机构：
[1] Med. Res. Cncl. Protein P., Dept. of Biochemistry, University of Dundee, Dundee
来源：
TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 09期
关键词：
D O I：
10.1016/S0962-8924(97)01105-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.
引用
收藏
页码：353 / 361
页数：9
相关论文
共 78 条
[1]   Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase [J].
Abe, J ;
Kusuhara, M ;
Ulevitch, RJ ;
Berk, BC ;
Lee, JD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16586-16590
[2]   Stimulation of mitogen-activated protein kinase and Na+/H+ exchanger in human platelets differential effect of phorbol ester and vasopressin [J].
Aharonovitz, O ;
Granot, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16494-16499
[3]   PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].
ALESSI, DR ;
CUENDA, A ;
COHEN, P ;
DUDLEY, DT ;
SALTIEL, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27489-27494
[4]  
BADGER AM, 1996, J PHARMACOL EXP THER, V279, P1458
[5]   Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB [J].
Barton, K ;
Muthusamy, N ;
Chanyangam, M ;
Fischer, C ;
Clendenin, C ;
Leiden, JM .
NATURE, 1996, 379 (6560) :81-85
[6]   The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor [J].
Beyaert, R ;
Cuenda, A ;
VandenBerghe, W ;
Plaisance, S ;
Lee, JC ;
Haegeman, G ;
Cohen, P ;
Fiers, W .
EMBO JOURNAL, 1996, 15 (08) :1914-1923
[7]   Phosphorylation and activation of cytosolic phospholipase A(2) by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets [J].
BorschHaubold, AG ;
Kramer, RM ;
Watson, SP .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 245 (03) :751-759
[8]   The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44(MAPK) cascade [J].
Brondello, JM ;
Brunet, A ;
Pouyssegur, J ;
McKenzie, FR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :1368-1376
[9]  
CAREW TJ, 1994, NEURON, V16, P5
[10]   INDUCTION OF C-FOS EXPRESSION THROUGH JNK-MEDIATED TCF/ELK-1 PHOSPHORYLATION [J].
CAVIGELLI, M ;
DOLFI, F ;
CLARET, FX ;
KARIN, M .
EMBO JOURNAL, 1995, 14 (23) :5957-5964
12345678