Long-term remission with rituximab in refractory leucine-rich glioma inactivated 1 antibody encephalitis

被引：27

作者：

Brown, J. William L. ^{[1
]}

Martin, Peter J. ^{[1
]}

Thorpe, John W. ^{[1
]}

Michell, Andrew W. ^{[1
]}

Coles, Alasdair J. ^{[1
]}

Cox, Amanda L. ^{[1
]}

Vincent, Angela ^{[2
]}

Zandi, Michael S. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Neurosci, Cambridge CB2 2QQ, England

[2] John Radcliffe Hosp, Neurosci Grp, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 271卷 / 1-2期

关键词：

VGKC; LGI1; Autoantibody; Rituximab; Encephalitis; Cognition;

D O I：

10.1016/j.jneuroim.2014.03.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoinimune encephalitis associated with antibodies to leucine-rich glioma inactivated 1 (LGI1) is recently described and there is a lack of detailed reports on the treatment of relapsing or refractory cases and long-term outcomes. Two case reports are presented. Both cases had faciobrachial dystonic seizures (FBDS) and received rituximab after relapsing or refractory disease. Both cases achieved sustained clinical remission of up to 15 and 56 months respectively. Rituximab use allowed withdrawal of corticosteroids and was well tolerated. Randomized clinical trials are needed in LGI1 encephalitis and other autoimmune encephalitides. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：66 / 68

页数：3

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