Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma

被引：6
作者：
Kang, Min H. [1 ]
Harutyunyan, Narine [2 ]
Hall, Connor P. [1 ]
Papa, Rachael A. [3 ]
Lock, Richard B. [3 ]
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Ctr Canc, Lubbock, TX 79430 USA
[2] Childrens Hosp Los Angeles, Div Hematol & Oncol, Los Angeles, CA 90027 USA
[3] Univ New S Wales, Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 145卷 / 03期
关键词：
methotrexate; aminopterin; antifolate; leukaemia; preclinical models; HIGH-DOSE METHOTREXATE; CELL-LINES; CHILDREN; PHARMACODYNAMICS; TRIAL;
D O I：
10.1111/j.1365-2141.2009.07631.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Due to the development of neurological toxicity and resistance to methotrexate (MTX), other antifolates have been evaluated for its potential replacement in the treatment of childhood acute lymphoblastic leukaemia (ALL). Aminopterin (AMT) has been suggested to provide clinical advantages over MTX and other antifolates. AMT activity, compared with MTX, was evaluated in ALL and lymphoma preclinical models. The minimum survival fraction at the range of concentrations tested was lower with AMT than with MTX in 3 out of 15 cell lines. Both AMT and MTX significantly extended the event-free survival of mice bearing 3 out of 4 xenografts with equivalent activity.
引用
收藏
页码：389 / 393
页数：5
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