Magnetofection: Magic magnetic nanoparticles for efficient gene delivery

被引：67
作者：
Bi, Qunjie [1 ]
Song, Xu [2 ]
Hu, Ao [1 ]
Luo, Tianying [1 ]
Jin, Rongrong [1 ]
Ai, Hua [1 ]
Nie, Yu [1 ]
机构：
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Inst Regulatory Sci Med Devices, Chengdu 610064, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Magnetic nanoparticles; Magentofection; Gene therapy; Biomedical applications; Combined therapy; IRON-OXIDE NANOPARTICLES; CELLULAR UPTAKE; CANCER; HYPERTHERMIA; FUNCTIONALIZATION; TRANSFECTION; MECHANISM; APOPTOSIS; VECTOR; SIRNA;
D O I：
10.1016/j.cclet.2020.07.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Magnetic nanoparticles (MNPs) have become a research hotspot and widely used in the biomedical field in recent decades due to their unique magnetic properties. This minireview summarizes the specific gene transfection of magnetic particles (magnetofection) during eversy dynamic process of gene delivery (gene binding, cellular uptake, endosomal escape, intracellular trafficking and in vivo targeting). Meanwhile, the synergistic biomedical application of magnetofection and the effects of MNPs have also been discussed, including magnetic resonance imaging (MRI), magnetic mediated hyperthermia (MMH), Fenton reaction and autophagy. Finally, the clinical prospect of magnetofection was briefly expected. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3041 / 3046
页数：6
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