Iron(II)-catalyzed direct C-H cyanoalkylation of 2H-indazoles and coumarins via radical C-C bond cleavage

被引：20

作者：

Gao, Pin ^{[1
]}

Cheng, Yuan-Bo ^{[1
]}

Yang, Fan ^{[1
]}

Guo, Li-Na ^{[1
]}

Duan, Xin-Hua ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, MOE Key Lab Nonequilibrium Synth & Modulat Conden, Xian Key Lab Sustainable Energy Mat Chem, Dept Chem,Sch Sci, Xian 710049, Shaanxi, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 35期

基金：

中国博士后科学基金;

关键词：

Iron; Cyanoalkylation; Heterocycles; Radical; REGIOSELECTIVE SYNTHESIS; RING-CLEAVAGE; OXIME ESTERS; FUNCTIONALIZATION; INHIBITORS; FLAVONES; ACCESS; ETHERS; ACIDS;

D O I：

10.1016/j.tetlet.2019.150967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iron-catalyzed C-3 cyanoalkylation of 2H-indazole and coumarin derivates with cyclobutanone oxime esters has been accomplished, which proceeds efficiently in a high regioselective manner to construct diverse alkylated 2H-indazole and coumarin derivates in moderate to good yields. Preliminary mechanistic studies reveal that a distal cyanosubstituted alkyl radicals intermediate would be formed through radical-involved C-C bond cleavage of cyclobutanone oximes ester. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：4

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