Tumorlike, iron-sparing foci of splenic hemosiderosis in a child with sickle cell anemia

An iron overload state is usually uncommon. in children. Patients with chronic hemolytic anemia who require repeated blood transfusions have a chronic iron overload and deposition of iron in the reticuloendothelial cells in the liver, spleen, and bone marrow.(1) Although hemosiderosis is a generalized disease, we report a case of selective splenic hemosiderosis presenting with a multifocal pattern of affection. Usually, the deposition of ferritin and hemosiderin in the reticuloendothelial cells is diffusely distributed within the parenchyma of the spleen.(2) Therefore, it is very rare for splenic hemosiderosis to present with a focal or. localized distribution. Also, hemosiderosis is not one of the differential diagnoses of multiple focal splenic masses, which are usually of traumatic, inflammatory, neoplastic, or vascular etiology.(3) In cases of multiple splenic masses, the main role of imaging modalities is to confirm or exclude splenic malignancy.