Human Papillomavirus Positivity in Women Undergoing Intrauterine Insemination Has a Negative Effect on Pregnancy Rates

被引:40
作者
Depuydt, Christophe E. [1 ]
Verstraete, Ludo [1 ]
Berth, Mario [1 ]
Beert, Johan [1 ,2 ]
Bogers, John-Paul [3 ]
Salembier, Geert [1 ]
Vereecken, Annie J. [1 ]
Bosmans, Eugene [1 ]
机构
[1] Sonic Healthcare, AML, Dept Hormonol & Reprod Hlth, BE-2020 Antwerp, Belgium
[2] Sonic Healthcare, AML, Intermediate Struct Human Body Mat, BE-2020 Antwerp, Belgium
[3] Sonic Healthcare, AML, Dept Clin & Mol Pathol, BE-2020 Antwerp, Belgium
关键词
Liquid-based cytology; Real-time quantitative PCR; Chlamydia trachomatis; Trichomonas vaginalis; SPONTANEOUSLY ABORTED PRODUCTS; TRICHOMONAS-VAGINALIS; INFECTION; PCR; DNA; ASSOCIATION; PREVALENCE; QUALITY; SAMPLES; SEMEN;
D O I
10.1159/000434749
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background: Sexually transmitted infections are a major cause of infertility. Human papillomavirus (HPV) infection is one of the most common viral infections of the female genital tract. Only a limited number of studies have investigated the influence of HPV on fertility and its impact remains controversial. Objective: We investigated the relationship between cervical HPV infection and pregnancy outcome after intrauterine insemination (IUD. Since other sexually transmitted infections could also influence outcome, we also analyzed the influence of Trichomonas vaginalis (TV) and Chlamydia trachomatis (CT) on pregnancy outcome. Methods: We performed a retrospective analysis of 590 women who underwent 1,529 IUI cycles at AML between 2010 and 2014. Positivity of 18 different HPV types (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68) and TV was assessed by PCR in cervical cytology specimens. CT status was ascertained by detection of IgA/IgG antibodies on serum samples or by PCR on cervical swabs. Results:The HPV prevalence per IUI cycle was 11.0 and 6.9% for CT; none of the women tested positive for TV. HPV-positive women were six times less likely to become pregnant after IUI (1.87 vs. 11.36%; p = 0.0041). There was no significant difference in pregnancy rates between women with or without a history of CT (8.51 vs. 11.10%; p >0.05). Conclusion: Detection of HPV is associated with a negative IUI outcome. (C) 2015 S. Karger AG, Basel
引用
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页码:41 / 46
页数:6
相关论文
共 34 条
[1]   European guidelines for quality assurance in cervical cancer screening: recommendations for collecting samples for conventional and liquid-based cytology [J].
Arbyn, M. ;
Herbert, A. ;
Schenck, U. ;
Nieminen, P. ;
Jordan, J. ;
Mcgoogan, E. ;
Patnick, J. ;
Bergeron, C. ;
Baldauf, J-J. ;
Klinkhamer, P. ;
Bulten, J. ;
Martin-Hirsch, P. .
CYTOPATHOLOGY, 2007, 18 (03) :133-139
[2]   Attendance at Cervical Cancer Screening and Use of Diagnostic and Therapeutic Procedures on the Uterine Cervix Assessed from Individual Health Insurance Data ( Belgium, 2002-2006) [J].
Arbyn, Marc ;
Fabri, Valerie ;
Temmerman, Marleen ;
Simoens, Cindy .
PLOS ONE, 2014, 9 (04)
[3]   Prior knowledge of HPV status improves detection of CIN2+ by cytology screening [J].
Benoy, Ina H. ;
Vanden Broeck, Davy ;
Ruymbeke, Maya J. ;
Sahebali, Shaira ;
Arbyn, Marc ;
Bogers, Johannes J. ;
Temmerman, Marleen ;
Depuydt, Christophe E. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2011, 205 (06) :569.e1-569.e7
[4]   Comparison of oral fluid and serum ELISAs in the determination of IgG response to natural human papillomavirus infection in university women [J].
Buchinsky, Farrel J. ;
Carter, Joseph J. ;
Wipf, Gregory C. ;
Hughes, James P. ;
Koutsky, Laura A. ;
Galloway, Denise A. .
JOURNAL OF CLINICAL VIROLOGY, 2006, 35 (04) :450-453
[5]  
Caliendo A M, 2005, Infect Dis Obstet Gynecol, V13, P145, DOI 10.1080/10647440500068248
[6]   Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection [J].
Carter, JJ ;
Koutsky, LA ;
Hughes, JP ;
Lee, SK ;
Kuypers, J ;
Kiviat, N ;
Galloway, DA .
JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (06) :1911-1919
[7]   Human papillomavirus infection and spontaneous abortion: a case-control study performed in Mexico [J].
Conde-Ferraez, Laura ;
Chan May, Alberto de A. ;
Carrillo-Martinez, Jorge R. ;
Ayora-Talavera, Guadalupe ;
del Refugio Gonzalez-Losa, Maria .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2013, 170 (02) :468-473
[8]   Pregnancy Outcomes From the Pregnancy Registry of a Human Papillomavirus Type 6/11/16/18 Vaccine [J].
Dana, Adrian ;
Buchanan, Karyn M. ;
Goss, Mary Ann ;
Seminack, Margaret M. ;
Shields, Kristine E. ;
Korn, Scott ;
Cunningham, Michael L. ;
Haupt, Richard M. .
OBSTETRICS AND GYNECOLOGY, 2009, 114 (06) :1170-1178
[9]   Comparison of MY09/11 consensus PCR and type-specific PCRs in the detection of oncogenic HPV types [J].
Depuydt, C. E. ;
Boulet, G. A. V. ;
Horvath, C. A. J. ;
Benoy, I. H. ;
Vereecken, A. J. ;
Bogers, J. J. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2007, 11 (04) :881-891
[10]   Improved endocervical sampling and HPV viral load detection by Cervex-Brush® Combi [J].
Depuydt, C. E. ;
Benoy, I. H. ;
Bailleul, E. J. ;
Vandepitte, J. ;
Vereecken, A. J. ;
Bogers, J. J. .
CYTOPATHOLOGY, 2006, 17 (06) :374-381