Objective Morphological Classification of Neocortical Pyramidal Cells

被引：43

作者：

Kanari, Lida ^{[1
]}

Ramaswamy, Srikanth ^{[1
]}

Shi, Ying ^{[1
]}

Morand, Sebastien ^{[2
]}

Meystre, Julie ^{[3
]}

Perin, Rodrigo ^{[3
]}

Abdellah, Marwan ^{[1
]}

Wang, Yun ^{[4
,5
]}

Hess, Kathryn ^{[2
]}

Markram, Henry ^{[1
,3
]}

机构：

[1] EPFL, Blue Brain Project, Brain & Mind Inst, Campus Biotech, CH-1202 Geneva, Switzerland

[2] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lab Topol & Neurosci, CH-1015 Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lab Neural Microcircuitry, CH-1015 Lausanne, Switzerland

[4] Wenzhou Med Coll, Sch Optometry & Ophthalmol, Wenzhou 325035, Zhejiang, Peoples R China

[5] Allen Inst Brain Sci, Seattle, WA 98109 USA

来源：

CEREBRAL CORTEX | 2019年 / 29卷 / 04期

基金：

中国国家自然科学基金;

关键词：

neuronal classification; neuronal morphology; pyramidal cells; rat somatosensory cortex; topological data analysis; RAT VISUAL-CORTEX; SOMATOSENSORY CORTEX; CALCIUM TRANSIENTS; ACTION-POTENTIALS; NEURONS; INTERNEURONS; CONNECTIONS; DIVERSITY; REPRESENTATION; NOMENCLATURE;

D O I：

10.1093/cercor/bhy339

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs. Therefore, we objectively identify 17 types of PCs in the rat somatosensory cortex. In addition, we provide a solution to the challenging problem of whether 2 similar neurons belong to different types or to a continuum of the same type. Our topological classification does not require expert input, is stable, and helps settle the long-standing debate on whether cell-types are discrete or continuous morphological variations of each other.

引用

页码：1719 / 1735

页数：17