Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

被引:194
作者
Yu, Ji-Yeon [1 ,2 ]
Ha, Jae Yeo [1 ,2 ]
Kim, Kyung-Mi [3 ]
Jung, Young-Suk [4 ]
Jung, Jae-Chul [3 ]
Oh, Seikwan [1 ,2 ]
机构
[1] Ewha Womans Univ, Dept Mol Med, Sch Med, Seoul 158710, South Korea
[2] Ewha Womans Univ, Tissue Injury Def Res Ctr, Sch Med, Seoul 158710, South Korea
[3] Novarex Co Ltd, Life Sci Res Inst, Cheongwon 363885, Chungbuk, South Korea
[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea
来源
MOLECULES | 2015年 / 20卷 / 07期
基金
新加坡国家研究基金会;
关键词
licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect; 18-BETA-GLYCYRRHETINIC ACID; BUTYL HYDROPEROXIDE; NITRIC-OXIDE; RAT; ANTIOXIDANT; INHIBITION; STRESS;
D O I
10.3390/molecules200713041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.
引用
收藏
页码:13041 / 13054
页数:14
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