Melatonin and regulation of autophagy: Mechanisms and therapeutic implications

被引：0

作者：

Wu, Jinjing ^{[1
]}

Bai, Yang ^{[1
]}

Wang, Yaguang ^{[1
]}

Ma, Jun ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Anesthesiol, Beijing Inst Heart Lung & Blood Vessel Dis, 2 Anzhen Rd, Beijing 100029, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 163卷

基金：

中国国家自然科学基金;

关键词：

Melatonin; Mitophagy; Ischemia/reperfusion injury; Cancer; Neurodegenerative diseases; CARDIAC ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; MITOPHAGIC CELL-DEATH; NEURONAL DEATH; MITOCHONDRIAL DYSFUNCTION; PERMEABILITY TRANSITION; DEPENDENT MITOPHAGY; EXCESSIVE MITOPHAGY; PARKINSONS-DISEASE; MEDIATES MITOPHAGY;

D O I：

10.1016/j.phrs.2020.105270

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondria are essential subcellular units that generate basic energy for the cell, as well as influence Ca2+ flux, apoptosis, and cell signaling. Mitophagy can selectively remove impaired mitochondria to preserve mitochondrial function, which is crucial for normal cellular maintenance. Mitochondrial dysfunction and mitophagy are widely reported to be linked to various pathogeneses. In addition, there is increasing evidence regarding the beneficial role of melatonin in the regulation and intervention of mitophagy progression. In this review, we focus on specific pathological conditions, including ischemia/reperfusion injury (IRI), cancer and neurodegenerative diseases, and elucidate the essential role of melatonin in the modulation of mitophagy in each of these distinct disorders.

引用

页数：13

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