Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease

被引：15

作者：

Alexiou, Athanasios ^{[1
]}

Soursou, Georgia ^{[1
,2
]}

Yarla, Nagendra Sastry ^{[3
]}

Ashraf, Ghulam Md ^{[4
]}

机构：

[1] Novel Global Community Educ Fdn, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

[2] Univ Crete, Med Sch, Bioinformat Grad Program, Iraklion, Greece

[3] GITAM Univ, Sch Life Sci, Dept Biochem & Bioinformat, Inst Sci, Visakhapatnam, Andhra Prades, India

[4] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2018年 / 19卷 / 09期

关键词：

Autism spectrum disorder; Alzheimer's disease; proteins; developmental origins of health and diseases; neurological symptoms; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E; DOWN-SYNDROME; BETA; TRANSMISSION; PLASTICITY; DEPOSITION; NUTRITION; PATHOLOGY; DENSITY;

D O I：

10.2174/1389203718666170911145321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer's Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.

引用

页码：876 / 880

页数：5

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