Enhanced Choice for Viewing Cocaine Pictures in Cocaine Addiction

被引：80

作者：

Moeller, Scott J. ^{[1
]}

Maloney, Thomas ^{[2
]}

Parvaz, Muhammad A. ^{[2
]}

Dunning, Jonathan P. ^{[2
,3
]}

Alia-Klein, Nelly ^{[2
]}

Woicik, Patricia A. ^{[2
]}

Hajcak, Greg ^{[3
]}

Telang, Frank ^{[2
]}

Wang, Gene-Jack ^{[2
]}

Volkow, Nora D. ^{[4
]}

Goldstein, Rita Z. ^{[2
]}

机构：

[1] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[2] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

[3] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA

[4] Natl Inst Drug Abuse, Directors Off, Bethesda, MD USA

来源：

BIOLOGICAL PSYCHIATRY | 2009年 / 66卷 / 02期

关键词：

Choice behavior; cocaine addiction; craving; IAPS pictures reward; neuropsychology; salience; unconscious motivation; DOPAMINE D2 RECEPTORS; NEUROANATOMICAL SPECIFICITY; ATTENTIONAL BIAS; MONETARY REWARD; USERS; STRESS; FOOD; CUES; BEHAVIOR; SEEKING;

D O I：

10.1016/j.biopsych.2009.02.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Individuals with cocaine use disorder (CUD) chose cocaine over nondrug rewards. in two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm. Methods: Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures-under explicit contingencies (choice made between two fully visible side-by-side images) and under more implicit contingencies (selections made between pictures hidden under flipped-over cards)-was examined in 20 CUD and 20 matched healthy control subjects. Subjects also provided self-reported ratings of each picture's pleasantness and arousal. Results: Under both contingencies, CUD subjects chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Furthermore, whereas CUD subjects' choice for viewing cocaine pictures exceeded choice for viewing unpleasant pictures (but did not exceed choice for viewing pleasant pictures, in contrast to their self-reported ratings), healthy control subjects avoided viewing cocaine pictures as frequently as, or even more than, unpleasant pictures. Finally, CUD subjects with the most cocaine viewing selections, even when directly compared with selections of the pleasant pictures, also reported the most frequent recent cocaine use. Conclusions: Enhanced drug-related choice in cocaine addiction can be demonstrated even for nonpharmacologic (pictorial) stimuli. This choice, which is modulated by alternative stimuli, partly transcends self-reports (possibly indicative of a disconnect in cocaine addiction between self-reports and objective behavior) to provide an objective marker of addiction severity. Neuroimaging studies are needed to establish the neural underpinnings of such enhanced cocaine-related choice.

引用

页码：169 / 176

页数：8

共 56 条

[51]

VOLKOW ND, 1990, AM J PSYCHIAT, V147, P719

[52] Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction [J].

Volkow, Nora D. ;

Wang, Gene-Jack ;

Telang, Frank ;

Fowler, Joanna S. ;

Logan, Jean ;

Childress, Anna-Rose ;

Jayne, Millard ;

Ma, Yeming ;

Wong, Christopher .

JOURNAL OF NEUROSCIENCE, 2006, 26 (24) :6583-6588

[53]

Wechsler D., 1999, WECHSLER ABBREVIATED

[54]

Woicik PA, 2009, NEUROPSYCHOPHARMACOL, V34, P1112, DOI 10.1038/npp.2008.60

[55] Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys [J].

Woolverton, WL ;

Anderson, KG .

PSYCHOPHARMACOLOGY, 2006, 186 (01) :99-106

[56] Neuroanatomical specificity of conditioned responses to cocaine versus food in mice [J].

Zombeck, Jonathan A. ;

Chen, Guan-Ting ;

Johnson, Zachary V. ;

Rosenberg, David M. ;

Craig, Adam B. ;

Rhodes, Justin S. .

PHYSIOLOGY & BEHAVIOR, 2008, 93 (03) :637-650

← 1 2 3 4 5 6 →