Carotid atherosclerosis among middle-aged individuals predicts cognition: A 10-year follow-up study

被引：18

作者：

Lin, Hsiu-Fen ^{[1
,2
]}

Huang, Ling-Chun ^{[1
,3
]}

Chen, Chun-Kai ^{[4
]}

Juo, Suh-Hang H. ^{[5
,6
,7
]}

Chen, Cheng-Sheng ^{[8
,9
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Neurol, Coll Med, Kaohsiung, Taiwan

[3] Kaohsiung Municipal Tatung Hosp, Dept Neurol, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Phys Med & Rehabil, Kaohsiung, Taiwan

[5] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[6] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[7] China Med Univ, Inst New Drug Dev, Taichung, Taiwan

[8] Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan

[9] Kaohsiung Med Univ, Dept Psychiat, Coll Med, Kaohsiung, Taiwan

来源：

ATHEROSCLEROSIS | 2020年 / 314卷

关键词：

Cognition; Intima-media thickness; Carotid plaque; Stiffness; Interaction; INTIMA-MEDIA THICKNESS; ARTERIAL STIFFNESS; RISK-FACTORS; CARDIOVASCULAR RISK; PROGRESSION; IMPAIRMENT; DEMENTIA; STROKE; ADULTS; INDEX;

D O I：

10.1016/j.atherosclerosis.2020.10.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: There is a lack of studies simultaneously evaluating the impact of structural and functional atherosclerosis on cognition. We investigated the long-term predictive and interaction effects of structural and functional carotid atherosclerosis markers on future cognitive decline. Methods: Five hundred and twenty-eight middle-aged participants enrolled in the carotid atherosclerosis examination in Kaohsiung Atherosclerosis Longitudinal Study (KALS) between 2006 and 2009 were tested for cognition between 2016 and 2019. The Montreal Cognitive Assessment (MoCA) was used for the cognitive test. Baseline structural atherosclerosis was assessed by carotid intima-media thickness (cIMT) and plaque, whereas functional atherosclerosis was evaluated by carotid stiffness (beta, Ep, and pulse wave velocity). Participants in the top quartile of cIMT and those with plaques were considered to have advanced structural atherosclerosis, whereas participants with all three stiffness parameters in the top quartile were defined to have advanced functional atherosclerosis. Results: The mean participant age at baseline was 53.88 +/- 8.37 years. Each case of advanced structural atherosclerosis and advanced functional atherosclerosis was associated with low 10-year MoCA scores with p < 0.001 and p = 0.03, respectively. An interaction effect was observed between structural and functional atherosclerosis on the MoCA score 10 years later (p = 0.02). Participants with both advanced structural and functional markers showed a marked impact on future cognitive function, especially executive and language domains. Conclusion: Carotid atherosclerosis in middle-aged individuals can predict their cognitive function in 10 years. Integrated information regarding both arterial wall and stiffness could help improve the predictive power for cognitive decline.

引用

页码：27 / 32

页数：6

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