A novel curcumin-artemisinin coamorphous solid: physical properties and pharmacokinetic profile

被引：70
作者：
Suresh, Kuthuru [1 ]
Mannava, M. K. Chaitanya [2 ]
Nangia, Ashwini [1 ,2 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
[2] Univ Hyderabad, Technol Business Incubator, Hyderabad 500046, Andhra Pradesh, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 102期
关键词：
DISSOLUTION RATE; QINGHAOSU ARTEMISININ; BIOAVAILABILITY; STABILITY; DISPERSION; DESIGN; POLYMORPHISM; COCRYSTALS; EUTECTICS; SYSTEMS;
D O I：
10.1039/c4ra11935e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Here we report a curcumin-artemisinin coamorphous solid (1 : 1) prepared by rotavaporization and a dramatic increase in the pharma-cokinetic profile of curcumin (AUC(0-12) 2.6 mu g h mL(-1), C-max 1 mu g mL(-1)) administered as CUR-ART to SD rats. PXRD and FESEM analysis explains the molecular basis for the solubility enhancement of coamorphous CUR-ART.
引用
收藏
页码：58357 / 58361
页数：5
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