Building Addressable Libraries: Site-Selective Lewis Acid (Scandium(III)) Catalyzed Reactions

被引：22
作者：
Bi, Bo [1 ]
Maurer, Karl [2 ]
Moeller, Kevin D. [1 ]
机构：
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
[2] CombiMatrix Corp, Mukilteo, WA 98275 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 32期
基金：
美国国家科学基金会;
关键词：
Diels-Alder reactions; Lewis acids; microelectrode arrays; multicomponent reactions; site-selective synthesis; MICROELECTRODE ARRAYS; TRIFLUOROMETHANESULFONATE;
D O I：
10.1002/anie.200902350
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reagent confinement: Lewis acid catalyzed reactions have been conducted on arrays with either 1024 or 12 544 microelectrodes cm-2. A Sc III species generated at the electrodes is employed as the Lewis acid, and the reagent is confined to the electrodes through the use of a solutionphase reductant. A multicomponent synthesis of a tetrahydropyran (see scheme), a Diels-Alder reaction, and an esterification reaction are all compatible with this strategy. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：5872 / 5874
页数：3
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