Luteophanol D, new polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

被引：43

作者：

Kubota, Takaaki ^{[1
]}

Takahashi, Ayako ^{[1
]}

Tsuda, Masashi ^{[1
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

MARINE DRUGS | 2005年 / 3卷 / 04期

关键词：

dinoflagellate; Amphidinium sp; luteophanol D; polyhydroxyl metabolite;

D O I：

10.3390/md304113

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Luteophanol D ( 1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol D ( 1) possesses two tetrahydropyran rings and twenty-three hydroxyl groups on C-63-linear aliphatic chain with one exo-methylene and two methyl branches.

引用

页码：113 / 118

页数：6

共 11 条

[1] Luteophanol A, a new polyhydroxyl compound from symbiotic marine dinoflagellate Amphidinium sp. [J].

Doi, Y ;

Ishibashi, M ;

Nakamichi, H ;

Kosaka, T ;

Ishikawa, T ;

Kobayashi, J .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (12) :3820-3823

[2] The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand [J].

Echigoya, R ;

Rhodes, L ;

Oshima, Y ;

Satake, M .

HARMFUL ALGAE, 2005, 4 (02) :383-389

[3] Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4 [J].

Houdai, T ;

Matsuoka, S ;

Murata, M ;

Satake, M ;

Ota, S ;

Oshima, Y ;

Rhodes, LL .

TETRAHEDRON, 2001, 57 (26) :5551-5555

[4] Lingshuiols A and B, two new polyhydroxy compounds from the Chinese marine dinoflagellate Amphidinium sp. [J].

Huang, XC ;

Zhao, D ;

Guo, YW ;

Wu, HM ;

Trivellone, E ;

Cimino, G .

TETRAHEDRON LETTERS, 2004, 45 (28) :5501-5504

[5] Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp. [J].

Huang, XC ;

Zhao, D ;

Guo, YW ;

Wu, HM ;

Lin, LP ;

Wang, ZH ;

Ding, J ;

Lin, YS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (12) :3117-3120

[6] Amphidinolides, bioactive macrolides from symbiotic marine dinoflagellates [J].

Kobayashi, J ;

Tsuda, M .

NATURAL PRODUCT REPORTS, 2004, 21 (01) :77-93

[7] Luteophanols B and C, new polyhydroxyl compounds from marine dinoflagellate Amphidinium sp [J].

Kubota, T ;

Tsuda, M ;

Doi, Y ;

Takahashi, A ;

Nakamichi, H ;

Ishibashi, M ;

Fukushi, E ;

Kawabata, J ;

Kobayashi, J .

TETRAHEDRON, 1998, 54 (48) :14455-14464

[8] Isolation and structure elucidation of a new amphidinol with a truncated polyhydroxyl chain from Amphidinium klebsii [J].

Morsy, N ;

Matsuoka, S ;

Houdai, T ;

Matsumori, N ;

Adachi, S ;

Murata, M ;

Iwashita, T ;

Fujita, T .

TETRAHEDRON, 2005, 61 (36) :8606-8610

[9] ISOLATION AND CHEMICAL-STRUCTURE OF AMPHIDINOL-2, A POTENT HEMOLYTIC COMPOUND FROM MARINE DINOFLAGELLATE AMPHIDINIUM-KLEBSII [J].

PAUL, GK ;

MATSUMORI, N ;

MURATA, M ;

TACHIBANA, K .

TETRAHEDRON LETTERS, 1995, 36 (35) :6279-6282

[10]

Paul GK, 1997, J MAR BIOTECHNOL, V5, P124

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