Enabling a systems biology approach to immunology: focus on innate immunity

被引：92

作者：

Gardy, Jennifer L. ^{[1
]}

Lynn, David J. ^{[2
]}

Brinkman, Fiona S. L. ^{[2
]}

Hancock, Robert E. W. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada

[2] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 06期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

PROTEIN-INTERACTION NETWORKS; GENE-EXPRESSION DATA; TOLL-LIKE-RECEPTORS; MACROPHAGE ACTIVATION; CHROMATIN IMMUNOPRECIPITATION; INTERACTION DATABASE; FUNCTIONAL GENOMICS; REGULATORY NETWORKS; ADAPTIVE IMMUNITY; CYTOSCAPE PLUGIN;

D O I：

10.1016/j.it.2009.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity.

引用

页码：249 / 262

页数：14

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