Relation Between Serum Total Bilirubin Levels and Severity of Coronary Artery Disease in Patients With Non-ST-Segment Elevation Myocardial Infarction

被引:37
作者
Kaya, Mehmet Gungor [1 ]
Sahin, Omer [1 ]
Akpek, Mahmut [1 ]
Duran, Mustafa [1 ]
Uysal, Onur Kadir [2 ]
Karadavut, Serhat [1 ]
Cosgun, M. Said [1 ]
Savas, Goktug [1 ]
Baktir, Ahmet Oguz [2 ]
Sarli, Bahadir [2 ]
Lam, Yat Yin [3 ]
机构
[1] Erciyes Univ, Sch Med, Dept Cardiol, TR-38039 Kayseri, Turkey
[2] Kayseri Educ & Res Hosp, Dept Cardiol, Kayseri, Turkey
[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Cardiol, Hong Kong, Hong Kong, Peoples R China
关键词
non-ST-segment elevation myocardial infarction; SYNTAX score; bilirubin; coronary artery disease; HEME OXYGENASE-1; SYNTAX SCORE; INTERVENTION; ATHEROSCLEROSIS;
D O I
10.1177/0003319713504820
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
We studied 403 consecutive patients with non-ST-segment elevation myocardial infarction (NSTEMI). This population was divided into tertiles according to the SYNTAX score (SXscore). The high SXscore group was defined as an SXscore >= 13, and the low SXscore group as an SXscore < 13. The total bilirubin (sTB) and direct bilirubin levels of patients were significantly higher in the high SXscore group (P = .001 and P = .007, respectively). There was a correlation between sTB and SXscore (r = .495; P = .005). On multivariate linear regression analyses, age (beta = .100; P = .041), sTB levels (beta = .171; P = .005), low-density lipoprotein cholesterol (beta = .121; P = .014), and troponin-I (beta = .124; P = .011) remained independent correlates of high SXscore. The mean follow-up period was 18.2 months. All-cause mortality rate was higher in the high SXscore group but did not reach significance (P = .058). In conclusion, high sTB level is independently associated with severity of coronary artery disease in patients with NSTEMI. However, no association was found with long-term mortality.
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收藏
页码:245 / 249
页数:5
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