Ameliorating effects of Tamarindus indica fruit extract on anti-tubercular drugs induced liver toxicity in rats

被引：22

作者：

Amir, Mohd ^{[1
]}

Khan, Mohammad Ahmed ^{[2
]}

Ahmad, Sayeed ^{[1
]}

Akhtar, Mohd ^{[2
]}

Mujeeb, Mohd ^{[1
]}

Ahmad, Aftab ^{[3
]}

Khan, Shah Alam ^{[4
]}

Al-Abbasi, Fahad A. ^{[5
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmacognosy & Phytochem, Bioact Nat Prod Lab, New Delhi 62, India

[2] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 62, India

[3] King Abdulaziz Univ, Jeddah Community Coll, Hlth Informat Technol Dept, Jeddah 21413, Saudi Arabia

[4] Oman Med Coll, Dept Pharm, Muscat, Oman

[5] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 06期

关键词：

DPPH-HPLC; hepatoprotective; Tamarindus indica; tuberculosis; ANTITUBERCULOSIS DRUGS; INDUCED HEPATOTOXICITY; PLANTS;

D O I：

10.1080/14786419.2015.1039001

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The study aimed to evaluate the hepatoprotective potential of aqueous extract of Tamarindus indica fruit against combination of two antitubercular drugs viz. Isoniazid and Rifampicin induced hepatotoxicity in rats. In vitro antioxidant activity of aqueous extract of T. indica by DPPH-HPLC method was found to be 81.48%. Treatment with aqueous extract of T. indica significantly reduced the elevated levels of biochemical markers such as SGOT, SGPT, ALP, bilirubin, TBARS and increased the albumin level as well antioxidant activities of SOD, CAT and GSH in intoxicated rats. The biochemical changes were supported by histological observations. Results of this study clearly demonstrate that aqueous extract of T. indica fruit protects against anti tuberculosis induced oxidative liver damage in rats and thus possess significant hepatoprotective activity. Further, it could be suggested that supplementation with this food extract might prove beneficial in the individuals on anti-TB drugs.

引用

页码：715 / 719

页数：5

共 15 条

[1] MODULATORY ACTIVITY OF ANTIOXIDANTS AGAINST THE TOXICITY OF RIFAMPICIN in vivo
Awodele, Olufunsho
Akintonwa, Alade
Osunkalu, Vincent O.
Coker, Herbert A. B.
[J]. REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 2010, 52 (01): : 43 - 46
[2] Genornics and the evolution, pathogenesis, and diagnosis of tuberculosis
Ernst, Joel D.
Trevejo-Nunez, Giraldina
Banaiee, Niaz
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (07) : 1738 - 1745
[3] Indian medicinal plants as a source of antimycobacterial agents
Gautam, Raju
Saklani, Arvind
Jachak, Sanjay M.
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2007, 110 (02) : 200 - 234
[4] Kumar V., ROBBINS BASIC PATHOL, V8th, P516
[5] Medical progress: Drug-induced hepatotoxicity
Lee, WM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (05) : 474 - 485
[6] Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters
Martinello, F.
Soares, S. M.
Franco, J. J.
Santos, A. C.
Sugohara, A.
Garcia, S. B.
Curti, C.
Uyemura, S. A.
[J]. FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (06) : 810 - 818
[7] Prajapati N.D., 2006, A Hand book of Medicinal Plants - A complete Source Book
[8] Rimbau V, 1999, PHYTOTHER RES, V13, P128, DOI 10.1002/(SICI)1099-1573(199903)13:2<128::AID-PTR399>3.0.CO
[9] 2-7
[10] Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats
Sasidharan, Suja Rani
Joseph, Joshua Allan
Anandakumar, Senthilkumar
Venkatesan, Vijayabalaji
Madhavan, Chandrasekharan Nair Ariyattu
Agarwal, Amit
[J]. SCIENTIFIC WORLD JOURNAL, 2014,

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