Determination of cysteine in a pharmaceutical formulation by flow injection analysis with a chemiluminescence detector

被引：96
|
作者：
Lau, CW [1 ]
Qin, XJ [1 ]
Liang, HY [1 ]
Lu, HZ [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
ANALYTICA CHIMICA ACTA | 2004年 / 514卷 / 01期
关键词：
cysteine; chemiluminescence; flow injection; pharmaceutical formulation;
D O I：
10.1016/j.aca.2004.01.007
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple and convenient flow injection-chemiluminescence (FI-CL) method for the determination of cysteine is reported, based on a fast and strong CL in a basic luminol-cysteine-NaIO4 solution. The linear range was 1.0 x 10(-8) to 1.0 X 10(-6) M with a detection limit (3s) of 5 x 10(-9) M, which was 100 times more sensitive than previously reported CL methods. Singlet oxygen, hydroxyl radical and hydrogen peroxide were suggested to be produced in this reaction and were responsible for the CL of cysteine. This simple method has been successfully applied for the determination of cysteine in a pharmaceutical formulation. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 49
页数：5
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