Determination of cysteine in a pharmaceutical formulation by flow injection analysis with a chemiluminescence detector

被引：96
|
作者：
Lau, CW [1 ]
Qin, XJ [1 ]
Liang, HY [1 ]
Lu, HZ [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
ANALYTICA CHIMICA ACTA | 2004年 / 514卷 / 01期
关键词：
cysteine; chemiluminescence; flow injection; pharmaceutical formulation;
D O I：
10.1016/j.aca.2004.01.007
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple and convenient flow injection-chemiluminescence (FI-CL) method for the determination of cysteine is reported, based on a fast and strong CL in a basic luminol-cysteine-NaIO4 solution. The linear range was 1.0 x 10(-8) to 1.0 X 10(-6) M with a detection limit (3s) of 5 x 10(-9) M, which was 100 times more sensitive than previously reported CL methods. Singlet oxygen, hydroxyl radical and hydrogen peroxide were suggested to be produced in this reaction and were responsible for the CL of cysteine. This simple method has been successfully applied for the determination of cysteine in a pharmaceutical formulation. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 49
页数：5
相关论文
共 50 条
  • [11] Determination of Polyamines by flow injection analysis with a chemiluminescence detector based on their complexation with copper(II)
    Li, Zheng-Ping
    Wu, Qiu-Hua
    Wang, Chun
    Su, Yu-Qin
    ANALYTICAL SCIENCES, 2006, 22 (05) : 763 - 767
  • [12] Determination of Polyamines by Flow Injection Analysis with a Chemiluminescence Detector Based on Their Complexation with Copper(II)
    Zheng-Ping Li
    Qiu-Hua Wu
    Chun Wang
    Yu-Qin Su
    Analytical Sciences, 2006, 22 : 763 - 767
  • [13] Determination of paracetamol by flow injection chemiluminescence analysis
    Chen, H
    Zhang, ZJ
    Fu, ZF
    CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2002, 30 (11) : 1344 - 1347
  • [14] Determination of ciprofloxacin in pharmaceutical formulation by chemiluminescence method
    Khan, M. A.
    Lee, S. H.
    Alam, S. M.
    Wabaidur, S. M.
    Chung, H. Y.
    LUMINESCENCE, 2008, 23 (02) : 76 - 76
  • [15] Determination of puerarin in pharmaceutical injection by flow injection analysis with acidic potassium permanganate-glyoxal chemiluminescence detection
    Wei, Gaili
    Wei, Chunlong
    Dang, Gaochao
    Yao, Hanchun
    Li, Hua
    ANALYTICAL LETTERS, 2007, 40 (11) : 2179 - 2191
  • [16] Recent progress in flow-injection chemiluminescence for pharmaceutical analysis
    Xue Bing-chun
    Wang Tao
    Liu Er-bao
    SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26 (05) : 816 - 820
  • [17] DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL FORMULATION BY CHEMILUMINESCENCE METHOD
    Khan, M. A.
    Lee, S. H.
    Alam, S. M.
    Wabaidur, S. M.
    Chung, H. Y.
    BIOLUMINESCENCE AND CHEMILUMINESCENCE, 2009, : 213 - 216
  • [18] Recent progress in flow-injection chemiluminescence for pharmaceutical analysis
    Xue, Bing-Chun
    Wang, Tao
    Liu, Er-Bao
    Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis, 2006, 26 (05): : 816 - 820
  • [19] Determination of ascorbic acid in pharmaceutical products by flow injection analysis using an amperometric detector
    Garrido, EM
    Lima, JLFC
    DelerueMatos, C
    FARMACO, 1995, 50 (12): : 881 - 884
  • [20] Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection
    Can, NO
    Tuncel, M
    Aboul-Enein, HY
    PHARMAZIE, 2003, 58 (01): : 22 - 24
12345